Winkler J, Block C, Leibovici L, Faktor J, Pitlik S D
Department of Medicine C, Beilinson Medical Center, Petah Tikva, Israel.
J Infect Dis. 1990 Dec;162(6):1400-2. doi: 10.1093/infdis/162.6.1400.
In view of recent observations on hormone-microorganism interactions, a study of Staphylococcus aureus nasal carriage in relation to sex-hormone status was undertaken. Prospectively in 479 women attending a colpocytologic clinic, hormonal status was assessed by determining the karyopyknotic index (KI) on smears stained by the Papanicolaou method. Rates of S. aureus nasal carriage were 29.3% in premenopausal women and 21.9% in postmenopausal women (P not significant). Carriage rates were significantly higher (P = .026, chi 2 7.32) for women with high KIs (40.7%) than for those with intermediate and low KIs (27.03% and 25.1%, respectively). S. aureus nasal carriage also correlated independently and significantly with previous antibiotic use and the presence of insulin-treated diabetes mellitus. This preliminary observation confirms an association between levels of sex hormones as reflected by the KI and S. aureus nasal carriage rates.
鉴于最近关于激素与微生物相互作用的观察结果，开展了一项关于金黄色葡萄球菌鼻腔携带情况与性激素状态关系的研究。前瞻性地对479名前往阴道细胞学诊所就诊的女性进行研究，通过在巴氏染色涂片上测定核固缩指数（KI）来评估激素状态。绝经前女性金黄色葡萄球菌鼻腔携带率为29.3%，绝经后女性为21.9%（P值无统计学意义）。KI值高的女性携带率显著更高（P = 0.026，χ² = 7.32）（40.7%），高于KI值中等和低的女性（分别为27.03%和25.1%）。金黄色葡萄球菌鼻腔携带还与既往抗生素使用及胰岛素治疗的糖尿病的存在独立且显著相关。这一初步观察结果证实了KI所反映的性激素水平与金黄色葡萄球菌鼻腔携带率之间的关联。
