Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway.
Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
PLoS One. 2019 Jul 5;14(7):e0218511. doi: 10.1371/journal.pone.0218511. eCollection 2019.
Use of hormonal contraceptives has been associated with Staphylococcus aureus nasal carriage in adult women. However, the role of hormonal contraceptives in S. aureus colonization among adolescents and associations with progestin only contraceptives are unknown.
We obtained nasal and throat swab samples from 439 girls aged 17-21 years in the population-based Tromsø study Fit Futures, 2012-2013, Norway, with information on lifestyle, health and biomarkers. We used multivariable logistic regression to study the association between use of hormonal contraceptives and Staphylococcus aureus carriage while adjusting for potential confounding factors.
Staphylococcus aureus nasal carriage prevalence were 34%, 42%, and 61% among progestin-only users, non-users, and progestin-estrogen combination contraceptive users, respectively (P<0.001). Use of combination contraceptives doubled the odds of nasal carriage (non-users reference; OR = 2.31, 95%CI = 1.43-3.74). The OR of nasal carriage was 0.29 among progestin-only users compared to combination contraceptives users (95% CI = 0.12-0.67).
In this study, use of combination hormonal contraceptives was associated with higher risk of Staphylococcus aureus nasal carriage in adolescent girls. Experimental design studies are needed to establish the role of exogenous sex steroids in Staphylococcus aureus colonization in women.
在成年女性中，使用激素避孕药与金黄色葡萄球菌鼻腔携带有关。然而，激素避孕药在青少年金黄色葡萄球菌定植中的作用以及与单纯孕激素避孕药的关系尚不清楚。
我们从挪威基于人群的特罗姆瑟未来健康研究中获得了 439 名 17-21 岁女孩的鼻腔和咽喉拭子样本，这些女孩在 2012-2013 年提供了生活方式、健康和生物标志物信息。我们使用多变量逻辑回归来研究激素避孕药的使用与金黄色葡萄球菌携带之间的关系，同时调整了潜在的混杂因素。
在使用单纯孕激素避孕药、未使用者和使用孕激素-雌激素联合避孕药的女性中，金黄色葡萄球菌鼻腔携带率分别为 34%、42%和 61%（P<0.001）。与未使用者相比，使用联合避孕药使鼻腔携带的几率增加了一倍（未使用者为参照；比值比=2.31，95%置信区间=1.43-3.74）。与联合避孕药使用者相比，单纯孕激素避孕药使用者鼻腔携带的比值比为 0.29（95%置信区间=0.12-0.67）。
在这项研究中，使用联合激素避孕药与青少年女孩金黄色葡萄球菌鼻腔携带的风险增加有关。需要进行实验设计研究来确定外源性性激素在女性金黄色葡萄球菌定植中的作用。
Zotero 插件