内分泌成纤维细胞生长因子 15/19 和 21：从盛宴到饥荒。
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.
机构信息
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, USA.
出版信息
Genes Dev. 2012 Feb 15;26(4):312-24. doi: 10.1101/gad.184788.111. Epub 2012 Feb 2.
Abstract
We review the physiology and pharmacology of two atypical fibroblast growth factors (FGFs)-FGF15/19 and FGF21-that can function as hormones. Both FGF15/19 and FGF21 act on multiple tissues to coordinate carbohydrate and lipid metabolism in response to nutritional status. Whereas FGF15/19 is secreted from the small intestine in response to feeding and has insulin-like actions, FGF21 is secreted from the liver in response to extended fasting and has glucagon-like effects. FGF21 also acts in an autocrine fashion in several tissues, including adipose. The pharmacological actions of FGF15/19 and FGF21 make them attractive drug candidates for treating metabolic disease.
摘要
我们回顾了两种可作为激素发挥作用的非典型成纤维细胞生长因子（FGF）-FGF15/19 和 FGF21 的生理学和药理学。FGF15/19 和 FGF21 均可作用于多种组织，以响应营养状况协调碳水化合物和脂质代谢。FGF15/19 是在进食时从小肠分泌的，具有胰岛素样作用，而 FGF21 则是在长时间禁食时由肝脏分泌的，具有胰高血糖素样作用。FGF21 还在包括脂肪组织在内的几种组织中以自分泌方式发挥作用。FGF15/19 和 FGF21 的药理作用使它们成为治疗代谢疾病的有吸引力的药物候选物。
相似文献
1
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine.内分泌成纤维细胞生长因子 15/19 和 21：从盛宴到饥荒。
Genes Dev. 2012 Feb 15;26(4):312-24. doi: 10.1101/gad.184788.111. Epub 2012 Feb 2.
2
Regulation of fibroblast growth factor 15/19 and 21 on metabolism: in the fed or fasted state.成纤维细胞生长因子15/19和21对代谢的调节：在进食或禁食状态下
J Transl Med. 2016 Mar 1;14:63. doi: 10.1186/s12967-016-0821-0.
3
Emerging role of fibroblast growth factors 15/19 and 21 as metabolic integrators in the liver.成纤维细胞生长因子 15/19 和 21 在肝脏中作为代谢整合因子的新作用。
Hepatology. 2012 Dec;56(6):2404-11. doi: 10.1002/hep.25929.
4
Hormone-like (endocrine) Fgfs: their evolutionary history and roles in development, metabolism, and disease.激素样（内分泌）FGFs：它们的进化历史及其在发育、代谢和疾病中的作用。
Cell Tissue Res. 2010 Oct;342(1):1-11. doi: 10.1007/s00441-010-1024-2. Epub 2010 Aug 24.
5
Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism.成纤维细胞生长因子19和21在减肥代谢中的作用
Dig Dis. 2017;35(3):191-196. doi: 10.1159/000450910. Epub 2017 Mar 1.
6
Metabolic roles of endocrine fibroblast growth factors.内分泌成纤维细胞生长因子的代谢作用。
Curr Opin Pharmacol. 2015 Dec;25:30-5. doi: 10.1016/j.coph.2015.09.014. Epub 2015 Oct 24.
7
Fibroblast growth factor 21: a novel metabolic regulator from pharmacology to physiology.成纤维细胞生长因子 21：从药理学到生理学的新型代谢调节剂。
Front Med. 2013 Mar;7(1):25-30. doi: 10.1007/s11684-013-0244-8. Epub 2013 Jan 28.
8
Fibroblast Growth Factor 21 Response in a Preclinical Alcohol Model of Acute-on-Chronic Liver Injury.成纤维细胞生长因子21在慢性肝损伤急性发作临床前酒精模型中的反应
Int J Mol Sci. 2021 Jul 23;22(15):7898. doi: 10.3390/ijms22157898.
9
Metabolic fibroblast growth factors (FGFs): Mediators of energy homeostasis.代谢性成纤维细胞生长因子（FGFs）：能量稳态的调节因子
Semin Cell Dev Biol. 2016 May;53:85-93. doi: 10.1016/j.semcdb.2015.09.021. Epub 2015 Sep 30.
10
Tissue-specific actions of the metabolic hormones FGF15/19 and FGF21.代谢激素FGF15/19和FGF21的组织特异性作用。
Trends Endocrinol Metab. 2015 Jan;26(1):22-9. doi: 10.1016/j.tem.2014.10.002. Epub 2014 Dec 1.
引用本文的文献
1
The role of HbA1c in the bidirectional relationship between periodontitis and diabetes and related interventions: a narrative review.糖化血红蛋白（HbA1c）在牙周炎与糖尿病双向关系及相关干预中的作用：一项叙述性综述
Front Nutr. 2025 Jun 17;12:1606223. doi: 10.3389/fnut.2025.1606223. eCollection 2025.
2
Secreted proteins in treating metabolic dysfunction-associated steatotic liver disease: from bench towards bedside.治疗代谢功能障碍相关脂肪性肝病的分泌蛋白：从 bench 到 bedside
Protein Cell. 2025 Aug 7;16(8):641-666. doi: 10.1093/procel/pwaf027.
3
Targeting Bile-Acid Metabolism: Nutritional and Microbial Approaches to Alleviate Ulcerative Colitis.靶向胆汁酸代谢：缓解溃疡性结肠炎的营养和微生物学方法
Nutrients. 2025 Mar 28;17(7):1174. doi: 10.3390/nu17071174.
4
Gut microbiota-mediated bile acid transformations regulate the transport of aflatoxin B1 from the intestine to the liver in piglets.肠道微生物群介导的胆汁酸转化调节仔猪中黄曲霉毒素B1从肠道到肝脏的转运。
J Anim Sci Biotechnol. 2025 Mar 8;16(1):38. doi: 10.1186/s40104-025-01169-x.
5
Hepatic fibroblast growth factor 21 is required for curcumin or resveratrol in exerting their metabolic beneficial effect in male mice.姜黄素或白藜芦醇在雄性小鼠中发挥代谢有益作用需要肝脏成纤维细胞生长因子21。
Nutr Diabetes. 2025 Feb 10;15(1):4. doi: 10.1038/s41387-025-00363-0.
6
Molecular mechanisms in liver repair and regeneration: from physiology to therapeutics.肝脏修复与再生的分子机制：从生理学到治疗学
Signal Transduct Target Ther. 2025 Feb 8;10(1):63. doi: 10.1038/s41392-024-02104-8.
7
FGF-based drug discovery: advances and challenges.基于成纤维细胞生长因子（FGF）的药物研发：进展与挑战
Nat Rev Drug Discov. 2025 May;24(5):335-357. doi: 10.1038/s41573-024-01125-w. Epub 2025 Jan 28.
8
Decoding FGF/FGFR Signaling: Insights into Biological Functions and Disease Relevance.解码成纤维细胞生长因子/成纤维细胞生长因子受体信号传导：对生物学功能和疾病相关性的见解
Biomolecules. 2024 Dec 18;14(12):1622. doi: 10.3390/biom14121622.
9
Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock.肝细胞周期 1 决定了氧化底物的选择，而不依赖于核心生物钟。
Cell Rep. 2024 Oct 22;43(10):114865. doi: 10.1016/j.celrep.2024.114865. Epub 2024 Oct 16.
10
Comprehensive in silico analysis of prognostic and immune infiltrates for FGFs in human ovarian cancer.全面的基于计算机的分析预测因子和免疫浸润物在人类卵巢癌中的 FGFs 作用。
J Ovarian Res. 2024 Oct 9;17(1):197. doi: 10.1186/s13048-024-01496-z.
本文引用的文献
1
Fibroblast growth factor 21 promotes bone loss by potentiating the effects of peroxisome proliferator-activated receptor γ.成纤维细胞生长因子 21 通过增强过氧化物酶体增殖物激活受体 γ 的作用促进骨丢失。
Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3143-8. doi: 10.1073/pnas.1200797109. Epub 2012 Feb 6.
2
Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.成纤维细胞生长因子 21 调节过氧化物酶体增殖物激活受体 γ 的活性和噻唑烷二酮类药物的抗糖尿病作用。
Cell. 2012 Feb 3;148(3):556-67. doi: 10.1016/j.cell.2011.11.062.
3
Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance.肥胖和胰岛素抵抗的两种小鼠模型中缺乏明显的 FGF21 抵抗。
Endocrinology. 2012 Jan;153(1):69-80. doi: 10.1210/en.2010-1262. Epub 2011 Nov 8.
4
The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 in the enterobiliary tract.人类胆囊将成纤维细胞生长因子 19 分泌到胆汁中：探索成纤维细胞生长因子 19 在肠胆通路中的作用。
Hepatology. 2012 Feb;55(2):575-83. doi: 10.1002/hep.24702. Epub 2011 Dec 19.
5
Time-imposed daily restricted feeding induces rhythmic expression of Fgf21 in white adipose tissue of mice.限时喂养会诱导小鼠白色脂肪组织中 Fgf21 的节律性表达。
Biochem Biophys Res Commun. 2011 Aug 26;412(2):396-400. doi: 10.1016/j.bbrc.2011.07.125. Epub 2011 Aug 3.
6
Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor?禁食和进食信号对人 FGF21 的双重调节：FGF21 是否是营养适应因子？
PLoS One. 2011;6(8):e22976. doi: 10.1371/journal.pone.0022976. Epub 2011 Aug 1.
7
Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo.体内成纤维细胞生长因子 21（FGF21）对肝脏代谢的综合调节。
Endocrinology. 2011 Aug;152(8):2996-3004. doi: 10.1210/en.2011-0281. Epub 2011 Jun 28.
8
FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1α pathway.成纤维细胞生长因子 15/19 通过抑制 CREB-PGC-1α 通路来调节肝脏的葡萄糖代谢。
Cell Metab. 2011 Jun 8;13(6):729-38. doi: 10.1016/j.cmet.2011.03.019.
9
Serum FGF21 levels are increased in newly diagnosed type 2 diabetes with nonalcoholic fatty liver disease and associated with hsCRP levels independently.血清 FGF21 水平在新诊断的 2 型糖尿病合并非酒精性脂肪性肝病患者中升高，并与 hsCRP 水平独立相关。
Diabetes Res Clin Pract. 2011 Jul;93(1):10-6. doi: 10.1016/j.diabres.2011.02.034. Epub 2011 May 18.
10
Serum concentrations of fibroblast growth factor 19 in patients with obesity and type 2 diabetes mellitus: the influence of acute hyperinsulinemia, very-low calorie diet and PPAR-α agonist treatment.肥胖症和 2 型糖尿病患者血清成纤维细胞生长因子 19 浓度：急性高胰岛素血症、极低热量饮食和过氧化物酶体增殖物激活受体-α 激动剂治疗的影响。
Physiol Res. 2011;60(4):627-36. doi: 10.33549/physiolres.932099. Epub 2011 May 16.
Zotero 插件