Marinus H, Buis B, van Benthem A
Philips Medical Systems Netherlands BV, Best.
Int J Card Imaging. 1990;5(2-3):173-82. doi: 10.1007/BF01833986.
A new angiographic method to calculate absolute coronary arterial blood flow and its cyclic variations as a function of time, has been designed and evaluated. The method combines densitometric analysis of spatial and temporal aspects concerning the contrast propagation through the arterial system from digital images, and is based on applying the concept of conservation of contrast material in successive images. It requires a standard arteriographic procedure. In simulations with both constant as well as pulsatile flow through a coronary arterial phantom, an excellent agreement with electromagnetic flow measurements was demonstrated (r = 0.993 and r = 0.982, respectively). Preliminary clinical results show, that the method yields reproducible assessment of coronary flow patterns after repeated injections in a patient. In a coronary artery bypass graft, coronary flow patterns in a baseline and a drug-induced hyperemic state were obtained. A consistent coronary flow reserve value was determined after repeated examinations. The method has been shown to be feasible in clinical applications, uncomplicated and fast, but requires further animal and clinical validation in order to determine the possible applications, limitations and accuracy.
一种用于计算绝对冠状动脉血流量及其随时间变化的周期性变化的新血管造影方法已被设计和评估。该方法结合了对通过数字图像中动脉系统的造影剂传播的空间和时间方面的密度分析，并基于在连续图像中应用造影剂守恒的概念。它需要标准的动脉造影程序。在通过冠状动脉模型进行的恒定流和脉动流模拟中，与电磁流量测量结果显示出极好的一致性（分别为r = 0.993和r = 0.982）。初步临床结果表明，该方法在患者重复注射后能够对冠状动脉血流模式进行可重复评估。在冠状动脉搭桥术中，获得了基线和药物诱导的充血状态下的冠状动脉血流模式。重复检查后确定了一致的冠状动脉血流储备值。该方法已被证明在临床应用中是可行的，简单且快速，但需要进一步的动物和临床验证，以确定其可能的应用、局限性和准确性。
