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神经网络中的非编码RNA，放心。

Non-Coding RNAs in Neural Networks, REST-Assured.

作者信息

Rossbach Michael

机构信息

Agency for Science, Technology and Research, Genome Institute of Singapore Singapore .

出版信息

Front Genet. 2011 Feb 28;2:8. doi: 10.3389/fgene.2011.00008. eCollection 2011.

DOI:10.3389/fgene.2011.00008
PMID:22303307
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3268567/
Abstract

In the nervous system, several key steps in cellular complexity and development are regulated by non-coding RNAs (ncRNAs) and the repressor element-1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF). REST recruits gene regulatory complexes to regulatory sequences, among them the repressor element-1/neuron-restrictive silencer element, and mediates developmental stage-specific gene expression or repression, chromatin (re-)organization or silencing for protein-coding genes as well as for several ncRNAs like microRNAs, short interfering RNAs or long ncRNAs. NcRNAs are far from being just transcriptional noise and are involved in chromatin accessibility, transcription and post-transcriptional processing, trafficking, or RNA editing. REST and its cofactor CoREST are both highly regulated through various ncRNAs. The importance of the correct regulation within the ncRNA network, the ncRNAome, is demonstrated when it comes to a deregulation of REST and/or ncRNAs associated with molecular pathophysiology underlying diverse disorders including neurodegenerative diseases or brain tumors.

摘要

在神经系统中，细胞复杂性和发育过程中的几个关键步骤由非编码RNA（ncRNA）和阻遏元件1沉默转录因子/神经元限制性沉默因子（REST/NRSF）调控。REST将基因调控复合物募集到调控序列，其中包括阻遏元件1/神经元限制性沉默元件，并介导发育阶段特异性基因表达或抑制、染色质（重新）组织或蛋白质编码基因以及几种ncRNA（如微小RNA、小干扰RNA或长链ncRNA）的沉默。ncRNA远非仅仅是转录噪音，它们参与染色质可及性、转录和转录后加工、运输或RNA编辑。REST及其辅因子CoREST均通过各种ncRNA受到高度调控。当涉及到REST和/或与包括神经退行性疾病或脑肿瘤在内的多种疾病的分子病理生理学相关的ncRNA的失调时，ncRNA网络（即ncRNA组）内正确调控的重要性就得到了体现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c4/3268567/ad2d80c80c6a/fgene-02-00008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c4/3268567/ad2d80c80c6a/fgene-02-00008-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c4/3268567/ad2d80c80c6a/fgene-02-00008-g001.jpg

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2
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Neurosci Lett. 2009 Dec 4;466(2):73-80. doi: 10.1016/j.neulet.2009.07.093. Epub 2009 Aug 11.
3
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新型可逆 LSD1 抑制剂 SP-2577 促进 SWI/SNF 复合物突变型卵巢癌中的抗肿瘤免疫。
PLoS One. 2020 Jul 10;15(7):e0235705. doi: 10.1371/journal.pone.0235705. eCollection 2020.
4
rs3796529 Genotype and Rate of Functional Deterioration in Alzheimer's Disease.rs3796529基因型与阿尔茨海默病的功能衰退率
Aging Dis. 2019 Feb 1;10(1):94-101. doi: 10.14336/AD.2018.0116. eCollection 2019 Feb.
5
Brain REST/NRSF Is Not Only a Silent Repressor but Also an Active Protector.脑REST/NRSF不仅是一个沉默的抑制因子，也是一个积极的保护因子。
Mol Neurobiol. 2017 Jan;54(1):541-550. doi: 10.1007/s12035-015-9658-4. Epub 2016 Jan 7.
6
REST-Governed Gene Expression Profiling in a Neuronal Cell Model Reveals Novel Direct and Indirect Processes of Repression and Up-Regulation.神经元细胞模型中由REST调控的基因表达谱揭示了新型的直接和间接抑制及上调过程。
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8
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RNA Biol. 2012 Nov;9(11):1380-96. doi: 10.4161/rna.22402. Epub 2012 Oct 12.
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Development. 2009 Mar;136(5):715-21. doi: 10.1242/dev.028548.
6
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RNA Biol. 2008 Oct-Dec;5(4):244-8. doi: 10.4161/rna.6948. Epub 2008 Oct 8.
7
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8
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