Dr. D.Y. Patil University, Pune, India.
Mini Rev Med Chem. 2012 May;12(5):412-25. doi: 10.2174/138955712800493870.
Mango tree, Mangifera indica, has been cultivated in India and several other tropical countries for centuries, and it is a good source of compound 'mangiferin'. Mangiferin's xanthonoid structure with C-glucosyl linkage and polyhydroxy component is believed to be crucial for its free radical-scavenging ability leading to a potent antioxidant effect. A number of biological activities of mangiferin have been suggested, including antidiabetic and antiinflammatory abilities. These might be explained by its antioxidant ability as well as its ability to modulate several key inflammatory pathways. Mangiferin has also been shown to be an effective inhibitor of NF-κB signaling pathway. This partially explains its antiinflammatory ability and, additionally, points towards its anticancer potential. The anticancer effects of this compound are just beginning to emerge, and in this comprehensive review, we provide information on what we know about the chemistry and biological effects of mangiferin, which would likely create interest among researchers to design further mechanistic studies in order to better understand and exploit the biological activities of this compound.
芒果树，Mangifera indica，在印度和其他几个热带国家已经种植了几个世纪，它是化合物“芒果苷”的良好来源。芒果苷的 C-葡萄糖基连接和多羟基成分的黄烷酮结构被认为对其清除自由基的能力至关重要，从而产生强大的抗氧化作用。已经提出了芒果苷的许多生物活性，包括抗糖尿病和抗炎能力。这可能是由于其抗氧化能力以及调节几个关键炎症途径的能力。芒果苷也被证明是 NF-κB 信号通路的有效抑制剂。这部分解释了其抗炎能力，此外，还表明了其抗癌潜力。这种化合物的抗癌作用才刚刚开始出现，在这个全面的综述中，我们提供了关于芒果苷的化学和生物学作用的信息，这可能会引起研究人员的兴趣，以设计进一步的机制研究，以便更好地理解和利用这种化合物的生物学活性。
