School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Biofactors. 2021 Jan;47(1):59-68. doi: 10.1002/biof.1693. Epub 2020 Nov 20.
Fibrosis is the end stage of many chronic diseases, which results in organ function failure and high mortality. Mangiferin is a major constituent in mango and other 16 plants, and has been shown a variety of pharmacological effects, such as antioxidant, antibacterial, anti-tumor, anti-inflammation. The emerging evidence has shown that mangiferin can improve renal interstitial fibrosis, pulmonary fibrosis, myocardial fibrosis and hepatic fibrosis through the inhibition of inflammation, oxidative stress and fibrogenesis effects, indicating that mangiferin is promising therapeutic choice for organ fibrosis. The aim of this review is to summarize the therapeutic effects of mangiferin on fibrosis of various organs and the underlying mechanisms.
纤维化是许多慢性疾病的终末期阶段，可导致器官功能衰竭和高死亡率。芒果苷是芒果和其他 16 种植物的主要成分，已显示出多种药理作用，如抗氧化、抗菌、抗肿瘤、抗炎。新出现的证据表明，芒果苷通过抑制炎症、氧化应激和纤维化作用，可改善肾间质纤维化、肺纤维化、心肌纤维化和肝纤维化，表明芒果苷是治疗器官纤维化的有前途的选择。本综述的目的是总结芒果苷对各种器官纤维化的治疗作用及其潜在机制。
