Motokawa S
Department of Orthopaedic Surgery, Nagasaki University, School of Medicine, Japan.
Nihon Seikeigeka Gakkai Zasshi. 1990 Sep;64(9):790-7.
It is well known that patients with Perthes' disease have skeletal growth disturbances such as short stature and retardation of bone maturation. The purpose of this study was to identify serum factors which relate to the skeletal growth disturbances in Perthes' disease. The stature, bone age and the concentration of plasma somatomedin-C were measured. The stature and bone age were lower than those of normal subjects, and the concentration of plasma somatomedin-C was significantly lower than the normal value. Serum from patients with Perthes' disease was added to the culture medium of chondrocytes from rabbit articular cartilage to measure the cell number and the contents of protein and glycosaminoglycan per dish. Each of these parameters was slightly lower in the culture containing the patients' serum than that with normal serum. It may be concluded that there is some factors in the serum of patients with Perthes' disease which controls the proliferation and differentiation of chondrocytes, and somatomedin-C might be related to that factor.
众所周知，患有佩吉特氏病的患者存在骨骼生长紊乱，如身材矮小和骨成熟延迟。本研究的目的是确定与佩吉特氏病骨骼生长紊乱相关的血清因子。测量了身高、骨龄和血浆生长调节素-C的浓度。身高和骨龄低于正常受试者，血浆生长调节素-C的浓度显著低于正常值。将佩吉特氏病患者的血清添加到兔关节软骨软骨细胞的培养基中，以测量每皿中的细胞数量以及蛋白质和糖胺聚糖的含量。在含有患者血清的培养物中，这些参数中的每一个都略低于含有正常血清的培养物。可以得出结论，佩吉特氏病患者的血清中存在一些控制软骨细胞增殖和分化的因子，生长调节素-C可能与该因子有关。
