Kitsugi T, Kasahara Y, Seto Y, Komai S
Department of Orthopaedic Surgery, Shiga Pediatric Orthopaedic Center, Japan.
Clin Orthop Relat Res. 1989 Jul(244):217-21.
In recent years, the association between somatomedin and Perthes' disease has been investigated. Somatomedin activity measured by different methods (i.e., bioassay and radioreceptor assay) has generated variable results. The purpose of this study was to examine plasma somatomedin-C activity in Perthes' disease using radioimmunoassay. Somatomedin-C activity in affected boys and girls between six and 11 years of age was normal compared to the standard data on normal children. It is difficult to prove a functional pituitary somatomedin target axis. Therefore, caution is advisable before hypothesizing an etiology of Perthes' disease on the basis of results of plasma somatomedin concentration.
近年来，已对生长调节素与佩特兹病之间的关联展开了研究。通过不同方法（即生物测定法和放射受体测定法）测得的生长调节素活性产生了不同的结果。本研究的目的是采用放射免疫测定法检测佩特兹病患儿的血浆生长调节素C活性。与正常儿童的标准数据相比，6至11岁患该病的男孩和女孩的生长调节素C活性正常。难以证明存在功能性垂体生长调节素靶轴。因此，在根据血浆生长调节素浓度结果对佩特兹病的病因进行假设之前，务必要谨慎。
