Tanaka H, Tamura K, Takano K, Inoue N, Yoshioka H, Odera K, Takaya Y, Ono T, Ando H, Taguchi Y
Acta Orthop Scand. 1984 Apr;55(2):135-40. doi: 10.3109/17453678408992324.
Serum somatomedin A, determined by radioreceptor assay in 47 children with Perthes' disease, was significantly reduced as compared to normal children of the same age. Nine children underwent the 1-Dopa tolerance tests to evoke growth hormone release; a normal response was found in eight. Patients with Perthes' disease tend to be short in stature with "disproportionate skeletal growth" of the limbs; growth is less in the distal than in the proximal extremities. The low serum levels of somatomedin A suggest some growth disturbance during the development of Perthes' disease.
通过放射受体分析法测定的47例 Perthes病患儿血清生长调节素A，与同龄正常儿童相比显著降低。9名儿童接受了左旋多巴耐量试验以激发生长激素释放；其中8名反应正常。Perthes病患者往往身材矮小，四肢骨骼生长“不成比例”；四肢远端的生长比近端少。血清生长调节素A水平低表明Perthes病发展过程中存在一些生长紊乱。
