Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. China.
Org Lett. 2012 Feb 17;14(4):1102-5. doi: 10.1021/ol3000124. Epub 2012 Feb 3.
Pallambins A (1) and B (2), two novel 19-nor-7,8-secolabdane diterpenoids with unprecedented tetracyclo[4.4.0(3,5).0(2,8)]decane skeletons, along with a pair of structurally related isomers, pallambins C (3) and D (4), were isolated from the Chinese liverwort Pallavicinia ambigua. Their structures with absolute configurations were determined by means of NMR, X-ray diffraction, and CD analyses. Their preliminary cytotoxicity to human cancer cells was also tested.
从中国产的地钱属植物 Pallavicinia ambigua 中分离得到两个新型的 19-降-7,8-断裂贝壳杉烷二萜类化合物 pallambins A (1) 和 B (2)，它们具有前所未有的四环[4.4.0(3,5).0(2,8)]癸烷骨架，以及一对结构相关的异构体 pallambins C (3) 和 D (4)。通过 NMR、X 射线衍射和 CD 分析确定了它们的结构和绝对构型。还测试了它们对人癌细胞的初步细胞毒性。
