来自中国肝叶苔属植物 Pallavicinia ambigua 的前所未有的六环 19-降螺甾烷二萜类化合物 Pallambins A 和 B。

Pallambins A and B, unprecedented hexacyclic 19-nor-secolabdane diterpenoids from the Chinese liverwort Pallavicinia ambigua.

机构信息

Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, P. R. China.

出版信息

Org Lett. 2012 Feb 17;14(4):1102-5. doi: 10.1021/ol3000124. Epub 2012 Feb 3.

DOI:10.1021/ol3000124

PMID:22304653

Abstract

Pallambins A (1) and B (2), two novel 19-nor-7,8-secolabdane diterpenoids with unprecedented tetracyclo[4.4.0(3,5).0(2,8)]decane skeletons, along with a pair of structurally related isomers, pallambins C (3) and D (4), were isolated from the Chinese liverwort Pallavicinia ambigua. Their structures with absolute configurations were determined by means of NMR, X-ray diffraction, and CD analyses. Their preliminary cytotoxicity to human cancer cells was also tested.

摘要

从中国产的地钱属植物 Pallavicinia ambigua 中分离得到两个新型的 19-降-7,8-断裂贝壳杉烷二萜类化合物 pallambins A (1) 和 B (2)，它们具有前所未有的四环[4.4.0(3,5).0(2,8)]癸烷骨架，以及一对结构相关的异构体 pallambins C (3) 和 D (4)。通过 NMR、X 射线衍射和 CD 分析确定了它们的结构和绝对构型。还测试了它们对人癌细胞的初步细胞毒性。