Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.
Chem Biodivers. 2012 Oct;9(10):2254-61. doi: 10.1002/cbdv.201100408.
One undescribed 6,7-secofusicoccane-type diterpene, albifolione (1), and one new aromadendrane-type sesquiterpenoid ketone, methyl 2-oxoaromadendra-1(10),3-dien-12-oate (2), along with four known compounds, δ-cuparenol (3), fusicoauritone (4), chiloscyphenols A and B (5 and 6, resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF-7, with an IC(50) value of 5.6 μM.
从叶附生苔类植物齿边短角苔（Bazzania albifolia Horik.）中分离得到一个新的未被描述的 6,7-二去甲福司可林型二萜化合物 albifolione（1）和一个新的莪术烷型倍半萜酮衍生物甲基 2-氧代莪术-1(10),3-二烯-12-酸酯（2），以及另外四个已知化合物：δ-古巴醇（3）、福司可林酮（4）、齿边短角苔酚 A 和 B（5 和 6）。基于光谱数据分析，明确建立了化合物 1 和 2 的结构和相对构型。初步的生物测定表明，化合物 5 对人肿瘤细胞系 MCF-7 表现出相当强的细胞毒性，IC50 值为 5.6 μM。
