从肝叶苔（Bazzania albifolia）中提取的生物活性倍半萜和二萜。

Bioactive sesquiterpenoids and diterpenoids from the liverwort Bazzania albifolia.

机构信息

Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, PR China.

出版信息

Chem Biodivers. 2012 Oct;9(10):2254-61. doi: 10.1002/cbdv.201100408.

DOI:10.1002/cbdv.201100408

PMID:23081925

Abstract

One undescribed 6,7-secofusicoccane-type diterpene, albifolione (1), and one new aromadendrane-type sesquiterpenoid ketone, methyl 2-oxoaromadendra-1(10),3-dien-12-oate (2), along with four known compounds, δ-cuparenol (3), fusicoauritone (4), chiloscyphenols A and B (5 and 6, resp.), were isolated from the liverwort Bazzania albifolia Horik. The structures and relative configurations of 1 and 2 were established unequivocally on the basis of spectroscopic data analysis. Preliminary bioassay revealed that compound 5 showed quite strong cytotoxicity against the human tumor cell line MCF-7, with an IC(50) value of 5.6 μM.

摘要

从叶附生苔类植物齿边短角苔（Bazzania albifolia Horik.）中分离得到一个新的未被描述的 6,7-二去甲福司可林型二萜化合物 albifolione（1）和一个新的莪术烷型倍半萜酮衍生物甲基 2-氧代莪术-1(10),3-二烯-12-酸酯（2），以及另外四个已知化合物：δ-古巴醇（3）、福司可林酮（4）、齿边短角苔酚 A 和 B（5 和 6）。基于光谱数据分析，明确建立了化合物 1 和 2 的结构和相对构型。初步的生物测定表明，化合物 5 对人肿瘤细胞系 MCF-7 表现出相当强的细胞毒性，IC50 值为 5.6 μM。