通过次碘酸盐催化的醚化反应在级联反应中构建芳基[5,5]螺缩酮。
Construction of aromatic [5,5] spiroketals via hypoiodite-catalyzed etherification combined in relay cascades.
机构信息
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China.
出版信息
Org Lett. 2012 Feb 17;14(4):1158-61. doi: 10.1021/ol300107v. Epub 2012 Feb 3.
PMID:22304671
Abstract
An approach is developed for the synthesis of bisbenzannelated spiro[5,5]ketals via a catalytic relay reaction cascade involving a new cyclo-etherification, which is prompted by fluoride and catalyzed by the hypoiodite species generated in situ from irradiative aerobic oxidation of an iodide ion formed in the former step of the reaction cascade.
摘要
开发了一种通过涉及新环醚化的催化接力反应级联合成双苯并annelated 螺[5.5]缩酮的方法，该方法由氟化物引发，并由反应级联的前一步中形成的碘化物离子的有氧氧化原位生成的次碘酸盐物种催化。
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