University of Otago, Wellington, New Zealand.
Emerg Infect Dis. 2012 Feb;18(2):226-33. doi: 10.3201/eid1802.111126.
Infection with Campylobacter spp. commonly precedes Guillain-Barré syndrome (GBS). We therefore hypothesized that GBS incidence may have followed a marked rise and then decline in campylobacteriosis rates in New Zealand. We reviewed records for 1988-2010: hospitalization records for GBS case-patients and campylobacteriosis case-patients plus notifications of campylobacteriosis. We identified 2,056 first hospitalizations for GBS, an average rate of 2.32 hospitalizations/100,000 population/year. Annual rates of hospitalization for GBS were significantly correlated with rates of notifications of campylobacteriosis. For patients hospitalized for campylobacteriosis, risk of being hospitalized for GBS during the next month was greatly increased. Three years after successful interventions to lower Campylobacter spp. contamination of fresh poultry meat, notifications of campylobacteriosis had declined by 52% and hospitalizations for GBS by 13%. Therefore, regulatory measures to prevent foodborne campylobacteriosis probably have an additional health and economic benefit of preventing GBS.
空肠弯曲菌感染通常先于格林-巴利综合征（GBS）。因此，我们假设新西兰弯曲杆菌病发病率的显著上升和下降可能与 GBS 的发病率有关。我们回顾了 1988 年至 2010 年的记录：GBS 病例患者和弯曲杆菌病病例患者的住院记录以及弯曲杆菌病的报告。我们确定了 2056 例首次住院的 GBS，平均每年每 100000 人口中有 2.32 例住院。GBS 的年住院率与弯曲杆菌病报告率显著相关。对于因弯曲杆菌病住院的患者，在下个月住院治疗 GBS 的风险大大增加。在成功实施降低新鲜禽肉中弯曲杆菌污染的干预措施三年后，弯曲杆菌病的报告率下降了 52%，GBS 的住院率下降了 13%。因此，预防食源性弯曲杆菌病的监管措施可能还有额外的健康和经济效益，可以预防 GBS。
