产气荚膜梭菌重组β 类毒素的生产与鉴定。
Production and characterization of Clostridium perfringens recombinant β toxoid.
机构信息
Centro de Desenvolvimento Tecnológico - Biotecnologia, Universidade Federal de Pelotas, RS, Brazil.
出版信息
Anaerobe. 2012 Jun;18(3):363-5. doi: 10.1016/j.anaerobe.2012.01.004. Epub 2012 Jan 24.
Abstract
In this work, we produced and evaluated a vaccine based on a β toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL(-1) of β antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.
摘要
在这项工作中，我们生产并评估了一种基于大肠杆菌（rBT）生产的 C 型产气荚膜梭菌β类毒素的疫苗。这种无毒的 rBT 对小鼠无害，并能诱导兔产生 14 IU mL(-1)的β抗毒素，符合欧洲药典和 CFR9 - USDA 指南的要求。
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