• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

GNAQ and GNA11 mutations in melanocytomas of the central nervous system.

作者信息

Murali Rajmohan, Wiesner Thomas, Rosenblum Marc K, Bastian Boris C

出版信息

Acta Neuropathol. 2012 Mar;123(3):457-9. doi: 10.1007/s00401-012-0948-x. Epub 2012 Feb 4.

DOI:10.1007/s00401-012-0948-x
PMID:22307269
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3495609/
Abstract
摘要

相似文献

1
GNAQ and GNA11 mutations in melanocytomas of the central nervous system.中枢神经系统黑素细胞瘤中的GNAQ和GNA11突变
Acta Neuropathol. 2012 Mar;123(3):457-9. doi: 10.1007/s00401-012-0948-x. Epub 2012 Feb 4.
2
Frequent and Yet Unreported GNAQ and GNA11 Mutations are Found in Uveal Melanomas.葡萄膜黑色素瘤中频繁出现但尚未报道的 GNAQ 和 GNA11 突变。
Pathol Oncol Res. 2019 Oct;25(4):1319-1325. doi: 10.1007/s12253-017-0371-7. Epub 2017 Dec 5.
3
The Role of Mutation Rates of GNAQ or GNA11 in Cases of Uveal Melanoma in Japan.GNAQ或GNA11突变率在日本葡萄膜黑色素瘤病例中的作用。
Appl Immunohistochem Mol Morphol. 2018 Oct;26(9):658-663. doi: 10.1097/PAI.0000000000000505.
4
GNAQ and GNA11 mutations occur in 9.5% of mucosal melanoma and are associated with poor prognosis.GNAQ 和 GNA11 突变发生于 9.5%的黏膜黑色素瘤中，与预后不良相关。
Eur J Cancer. 2016 Sep;65:156-63. doi: 10.1016/j.ejca.2016.06.019. Epub 2016 Aug 4.
5
Mutations in g protein encoding genes and chromosomal alterations in primary leptomeningeal melanocytic neoplasms.原发性柔脑膜黑素细胞肿瘤中G蛋白编码基因的突变及染色体改变。
Pathol Oncol Res. 2015 Apr;21(2):439-47. doi: 10.1007/s12253-014-9841-3. Epub 2014 Oct 15.
6
Mutation scanning of BRAF, NRAS, KIT, and GNAQ/GNA11 in oral mucosal melanoma: a study of 57 cases.口腔黏膜黑色素瘤中BRAF、NRAS、KIT和GNAQ/GNA11的突变扫描：57例研究
J Oral Pathol Med. 2016 Apr;45(4):295-301. doi: 10.1111/jop.12358. Epub 2015 Sep 24.
7
Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.GNAQ 基因的激活突变：中枢神经系统原发性黑色素细胞肿瘤的常见事件。
Acta Neuropathol. 2010 Mar;119(3):317-23. doi: 10.1007/s00401-009-0611-3.
8
Patient survival in uveal melanoma is not affected by oncogenic mutations in GNAQ and GNA11.葡萄膜黑色素瘤患者的生存不受 GNAQ 和 GNA11 致癌突变的影响。
Br J Cancer. 2013 Jul 23;109(2):493-6. doi: 10.1038/bjc.2013.299. Epub 2013 Jun 18.
9
Immunohistochemical and molecular pathology of ocular uveal melanocytoma: evidence for somatic GNAQ mutations.眼葡萄膜黑素细胞瘤的免疫组织化学和分子病理学：GNAQ 基因体细胞突变的证据。
Br J Ophthalmol. 2013 Jul;97(7):924-8. doi: 10.1136/bjophthalmol-2013-303291. Epub 2013 May 17.
10
Mutations in GNA11 in uveal melanoma.GNA11 基因突变与葡萄膜黑色素瘤。
N Engl J Med. 2010 Dec 2;363(23):2191-9. doi: 10.1056/NEJMoa1000584. Epub 2010 Nov 17.

引用本文的文献

1
Longest survival with primary intracranial malignant melanoma: A case report and literature review.原发性颅内恶性黑色素瘤的最长生存期：一例报告及文献综述
World J Clin Cases. 2022 Oct 26;10(30):11162-11171. doi: 10.12998/wjcc.v10.i30.11162.
2
Primary Melanocytomas of the Spinal Cord: Case Studies and Rehabilitation Perspectives.脊髓原发性黑素细胞瘤：病例研究与康复前景
Arch Rehabil Res Clin Transl. 2021 Aug 5;3(3):100143. doi: 10.1016/j.arrct.2021.100143. eCollection 2021 Sep.
3
Functional characterization of uveal melanoma oncogenes.葡萄膜黑色素瘤癌基因的功能特性
Oncogene. 2021 Jan;40(4):806-820. doi: 10.1038/s41388-020-01569-5. Epub 2020 Dec 1.
4
Clinicopathological and prognostic significance and molecular mechanisms governing uveal melanoma.葡萄膜黑色素瘤的临床病理特征、预后意义及分子机制
Ther Adv Med Oncol. 2020 Jun 8;12:1758835920917566. doi: 10.1177/1758835920917566. eCollection 2020.
5
Primary spinal cord melanocytoma: a case report and review of literature.原发性脊髓黑素细胞瘤：一例报告并文献复习
Int J Clin Exp Pathol. 2019 Feb 1;12(2):669-673. eCollection 2019.
6
Primary sellar melanocytoma: pathological, clinical and treatment review.原发性鞍内黑色素细胞瘤：病理、临床和治疗回顾。
J Endocrinol Invest. 2020 May;43(5):575-585. doi: 10.1007/s40618-019-01158-8. Epub 2019 Dec 3.
7
GNAQ Q209R Mutations Are Highly Specific for Circumscribed Choroidal Hemangioma.GNAQ基因Q209R突变对外生性脉络膜血管瘤具有高度特异性。
Cancers (Basel). 2019 Jul 22;11(7):1031. doi: 10.3390/cancers11071031.
8
Focus on cutaneous and uveal melanoma specificities.关注皮肤和葡萄膜黑色素瘤的特异性。
Genes Dev. 2017 Apr 15;31(8):724-743. doi: 10.1101/gad.296962.117.
9
Activating CYSLTR2 and PLCB4 Mutations in Primary Leptomeningeal Melanocytic Tumors.原发性软脑膜黑素细胞肿瘤中CYSLTR2和PLCB4激活突变
J Invest Dermatol. 2017 Sep;137(9):2033-2035. doi: 10.1016/j.jid.2017.04.022. Epub 2017 May 10.
10
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.一名青春期女孩患有散发型黑素性神经鞘瘤，具有黑素细胞瘤的重叠特征，且携带GNA11突变。
Pediatr Blood Cancer. 2017 Jun;64(6). doi: 10.1002/pbc.26400. Epub 2016 Dec 24.

本文引用的文献

1
Mutations in GNA11 in uveal melanoma.GNA11 基因突变与葡萄膜黑色素瘤。
N Engl J Med. 2010 Dec 2;363(23):2191-9. doi: 10.1056/NEJMoa1000584. Epub 2010 Nov 17.
2
Activating mutations of the GNAQ gene: a frequent event in primary melanocytic neoplasms of the central nervous system.GNAQ 基因的激活突变：中枢神经系统原发性黑色素细胞肿瘤的常见事件。
Acta Neuropathol. 2010 Mar;119(3):317-23. doi: 10.1007/s00401-009-0611-3.
3
Schwann cell precursors from nerve innervation are a cellular origin of melanocytes in skin.来自神经支配的雪旺细胞前体是皮肤中黑素细胞的细胞起源。
Cell. 2009 Oct 16;139(2):366-79. doi: 10.1016/j.cell.2009.07.049.
4
Independent regulation of hair and skin color by two G protein-coupled pathways.两个 G 蛋白偶联途径对毛发和皮肤颜色的独立调控。
Pigment Cell Melanoma Res. 2009 Dec;22(6):819-26. doi: 10.1111/j.1755-148X.2009.00609.x. Epub 2009 Jul 21.
5
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi.葡萄膜黑色素瘤和蓝色痣中GNAQ的频繁体细胞突变。
Nature. 2009 Jan 29;457(7229):599-602. doi: 10.1038/nature07586. Epub 2008 Dec 10.
6
Uveal melanoma: location, size, cell type, and enucleation as risk factors in metastasis.
Hum Pathol. 1982 Feb;13(2):123-32. doi: 10.1016/s0046-8177(82)80116-0.