University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, UK.
J Clin Invest. 2012 Mar;122(3):804-7. doi: 10.1172/JCI62595. Epub 2012 Feb 6.
Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies. However, previous attempts to manipulate BAT's sympathetic activation have lacked specificity. In this issue of the JCI, Bordicchia et al. provide new data indicating that cardiac natriuretic peptides (NPs) are also able to activate thermogenic machinery in adipose tissue. Their findings suggest a novel strategy to increase energy dissipation in adipose tissue, independent of adrenergic receptors.
棕色脂肪组织（BAT）中的产热作用受交感神经系统的控制，这一特点已得到充分证实。BAT 的能量消耗能力使其成为抗肥胖治疗的一个有吸引力的靶点。然而，以前操纵 BAT 交感神经激活的尝试缺乏特异性。在本期 JCI 中，Bordicchia 等人提供了新的数据，表明心脏利钠肽（NPs）也能够激活脂肪组织中的产热机制。他们的研究结果表明了一种增加脂肪组织能量消耗的新策略，这种策略与肾上腺素受体无关。
