NPs--调节棕色脂肪的心脏激素？
NPs -- heart hormones that regulate brown fat?
机构信息
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Cambridge, UK.
出版信息
J Clin Invest. 2012 Mar;122(3):804-7. doi: 10.1172/JCI62595. Epub 2012 Feb 6.
Abstract
Thermogenesis in brown adipose tissue (BAT) is well characterized as being under the control of the sympathetic nervous system. The energy-burning capacity of BAT makes it an attractive target for anti-obesity therapies. However, previous attempts to manipulate BAT's sympathetic activation have lacked specificity. In this issue of the JCI, Bordicchia et al. provide new data indicating that cardiac natriuretic peptides (NPs) are also able to activate thermogenic machinery in adipose tissue. Their findings suggest a novel strategy to increase energy dissipation in adipose tissue, independent of adrenergic receptors.
摘要
棕色脂肪组织（BAT）中的产热作用受交感神经系统的控制，这一特点已得到充分证实。BAT 的能量消耗能力使其成为抗肥胖治疗的一个有吸引力的靶点。然而，以前操纵 BAT 交感神经激活的尝试缺乏特异性。在本期 JCI 中，Bordicchia 等人提供了新的数据，表明心脏利钠肽（NPs）也能够激活脂肪组织中的产热机制。他们的研究结果表明了一种增加脂肪组织能量消耗的新策略，这种策略与肾上腺素受体无关。
相似文献
1
NPs -- heart hormones that regulate brown fat?NPs--调节棕色脂肪的心脏激素？
J Clin Invest. 2012 Mar;122(3):804-7. doi: 10.1172/JCI62595. Epub 2012 Feb 6.
2
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.心钠肽通过 p38MAPK 作用诱导鼠和人脂肪细胞中褐色脂肪产热程序。
J Clin Invest. 2012 Mar;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.
3
Role of Exercise in the Activation of Brown Adipose Tissue.运动在棕色脂肪组织激活中的作用。
Ann Nutr Metab. 2015;67(1):21-32. doi: 10.1159/000437173. Epub 2015 Jul 25.
4
Lipocalin 2 regulates brown fat activation via a nonadrenergic activation mechanism.脂质运载蛋白2通过非肾上腺素能激活机制调节棕色脂肪激活。
J Biol Chem. 2014 Aug 8;289(32):22063-77. doi: 10.1074/jbc.M114.559104. Epub 2014 Jun 10.
5
Translational Pharmacology and Physiology of Brown Adipose Tissue in Human Disease and Treatment.棕色脂肪组织在人类疾病与治疗中的转化药理学与生理学
Handb Exp Pharmacol. 2019;251:381-424. doi: 10.1007/164_2018_184.
6
A heart-adipose tissue connection in the regulation of energy metabolism.心脏-脂肪组织连接在能量代谢调节中的作用。
Nat Rev Endocrinol. 2014 Mar;10(3):157-63. doi: 10.1038/nrendo.2013.234. Epub 2013 Dec 3.
7
The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe.利钠肽在棕色脂肪细胞中的产热作用：使用荧光热探针直接测量细胞内温度。
Sci Rep. 2017 Oct 11;7(1):12978. doi: 10.1038/s41598-017-13563-1.
8
Elucidation of the roles of brown and brite fat genes: GPR120 is a modulator of brown adipose tissue function.阐明棕色脂肪和米色脂肪基因的作用：GPR120是棕色脂肪组织功能的调节因子。
Exp Physiol. 2020 Aug;105(8):1201-1205. doi: 10.1113/EP087877. Epub 2020 Mar 29.
9
Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice.促红细胞生成素（EPO）通过促进饮食诱导的肥胖小鼠经典棕色脂肪组织（BAT）的产热和内分泌功能，改善肥胖和葡萄糖稳态。
PLoS One. 2017 Mar 13;12(3):e0173661. doi: 10.1371/journal.pone.0173661. eCollection 2017.
10
Weighing in on the role of brown adipose tissue for treatment of obesity.探讨棕色脂肪组织在肥胖治疗中的作用。
J Pharm Pharm Sci. 2024 Jul 17;27:13157. doi: 10.3389/jpps.2024.13157. eCollection 2024.
引用本文的文献
1
Heart Failure With Preserved Ejection Fraction and Adipose Tissue: A Story of Two Tales.射血分数保留的心力衰竭与脂肪组织：两个故事
Front Cardiovasc Med. 2019 Aug 2;6:110. doi: 10.3389/fcvm.2019.00110. eCollection 2019.
2
The thermogenic actions of natriuretic peptide in brown adipocytes: The direct measurement of the intracellular temperature using a fluorescent thermoprobe.利钠肽在棕色脂肪细胞中的产热作用：使用荧光热探针直接测量细胞内温度。
Sci Rep. 2017 Oct 11;7(1):12978. doi: 10.1038/s41598-017-13563-1.
3
Increased Hydration Can Be Associated with Weight Loss.增加水分摄入可能与体重减轻有关。
Front Nutr. 2016 Jun 10;3:18. doi: 10.3389/fnut.2016.00018. eCollection 2016.
4
Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.骨骼与肌肉的内分泌功能：器官间通讯的意外模式
Cell. 2016 Mar 10;164(6):1248-1256. doi: 10.1016/j.cell.2016.02.043.
5
Heart Failure With Preserved Ejection Fraction Induces Beiging in Adipose Tissue.射血分数保留的心力衰竭可诱导脂肪组织发生米色化。
Circ Heart Fail. 2016 Jan;9(1):e002724. doi: 10.1161/CIRCHEARTFAILURE.115.002724.
6
The association of liver enzymes with biomarkers of subclinical myocardial damage and structural heart disease.肝脏酶与亚临床心肌损伤及结构性心脏病生物标志物的关联。
J Hepatol. 2015 Apr;62(4):841-7. doi: 10.1016/j.jhep.2014.11.024. Epub 2014 Nov 27.
7
β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors.β-氨基异丁酸诱导白色脂肪褐变和肝脏β氧化，与心血管代谢风险因素呈负相关。
Cell Metab. 2014 Jan 7;19(1):96-108. doi: 10.1016/j.cmet.2013.12.003.
8
Irisin, two years later.鸢尾素，两年后。
Int J Endocrinol. 2013;2013:746281. doi: 10.1155/2013/746281. Epub 2013 Nov 5.
9
Brown adipose tissue growth and development.棕色脂肪组织的生长与发育。
Scientifica (Cairo). 2013;2013:305763. doi: 10.1155/2013/305763. Epub 2013 Mar 31.
10
Heart hormones fueling a fire in fat.心脏激素为脂肪燃烧提供动力。
Adipocyte. 2013 Apr 1;2(2):104-8. doi: 10.4161/adip.22515.
本文引用的文献
1
Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes.心钠肽通过 p38MAPK 作用诱导鼠和人脂肪细胞中褐色脂肪产热程序。
J Clin Invest. 2012 Mar;122(3):1022-36. doi: 10.1172/JCI59701. Epub 2012 Feb 6.
2
Orexin is required for brown adipose tissue development, differentiation, and function.食欲素对于棕色脂肪组织的发育、分化和功能是必需的。
Cell Metab. 2011 Oct 5;14(4):478-90. doi: 10.1016/j.cmet.2011.08.010.
3
Natriuretic peptides and their receptors.利钠肽及其受体。
FEBS J. 2011 Jun;278(11):1791. doi: 10.1111/j.1742-4658.2011.08114.x. Epub 2011 May 9.
4
Outdoor temperature, age, sex, body mass index, and diabetic status determine the prevalence, mass, and glucose-uptake activity of 18F-FDG-detected BAT in humans.户外温度、年龄、性别、体重指数和糖尿病状态决定了 18F-FDG 检测到的人类 BAT 的患病率、质量和葡萄糖摄取活性。
J Clin Endocrinol Metab. 2011 Jan;96(1):192-9. doi: 10.1210/jc.2010-0989. Epub 2010 Oct 13.
5
NO modulates the molecular basis of rat interscapular brown adipose tissue thermogenesis.NO 调节大鼠肩胛间棕色脂肪组织产热的分子基础。
Comp Biochem Physiol C Toxicol Pharmacol. 2010 Aug;152(2):147-59. doi: 10.1016/j.cbpc.2010.03.008. Epub 2010 Apr 2.
6
Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.肝 FGF21 表达在出生时通过 PPARalpha 被诱导，以响应奶的摄入，并有助于新生儿棕色脂肪的产热激活。
Cell Metab. 2010 Mar 3;11(3):206-12. doi: 10.1016/j.cmet.2010.02.001.
7
High incidence of metabolically active brown adipose tissue in healthy adult humans: effects of cold exposure and adiposity.健康成年人中代谢活跃的棕色脂肪组织发生率高：寒冷暴露和肥胖的影响。
Diabetes. 2009 Jul;58(7):1526-31. doi: 10.2337/db09-0530. Epub 2009 Apr 28.
8
Identification and importance of brown adipose tissue in adult humans.成人棕色脂肪组织的识别及其重要性。
N Engl J Med. 2009 Apr 9;360(15):1509-17. doi: 10.1056/NEJMoa0810780.
9
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure.骨形态发生蛋白7在棕色脂肪生成和能量消耗中的新作用。
Nature. 2008 Aug 21;454(7207):1000-4. doi: 10.1038/nature07221.
10
PRDM16 controls a brown fat/skeletal muscle switch.PRDM16控制棕色脂肪/骨骼肌转换。
Nature. 2008 Aug 21;454(7207):961-7. doi: 10.1038/nature07182.
Zotero 插件