Karsenty Gerard, Olson Eric N
Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Cell. 2016 Mar 10;164(6):1248-1256. doi: 10.1016/j.cell.2016.02.043.
Most physiological functions originate with the communication between organs. Mouse genetics has revived this holistic view of physiology through the identification of inter-organ communications that are unanticipated, functionally important, and would have been difficult to uncover otherwise. This Review highlights this point by showing how two tissues usually not seen as endocrine ones, bone and striated muscles, influence several physiological processes in a significant manner.
大多数生理功能源于器官之间的通讯。小鼠遗传学通过鉴定出器官间那些意想不到的、具有重要功能且原本难以发现的通讯方式，使生理学的这种整体观得以复兴。本综述通过展示两种通常不被视为内分泌组织的组织——骨骼和横纹肌——如何以显著方式影响多个生理过程，突出了这一点。
