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一种禽源H1N1流感病毒血凝素基因的分子分析

Molecular analysis of the haemagglutinin gene of an avian H1N1 influenza virus.

作者信息

Austin F J, Kawaoka Y, Webster R G

机构信息

Virus Research Unit, University of Otago, Dunedin, New Zealand.

出版信息

J Gen Virol. 1990 Oct;71 ( Pt 10):2471-4. doi: 10.1099/0022-1317-71-10-2471.

DOI:10.1099/0022-1317-71-10-2471
PMID:2230742
Abstract

This study presents the first nucleotide sequence and deduced primary amino acid sequence of a subtype H1 haemagglutinin from the avian influenza virus A/duck/Alberta/35/76 (H1N1). The molecule is structurally, antigenically and molecularly similar to H1 haemagglutinins of human viruses but sequence homology differences indicate that there has not been a recent transfer of haemagglutinin genetic information between them.

摘要

本研究展示了来自禽流感病毒A/鸭/艾伯塔/35/76(H1N1)的H1亚型血凝素的首个核苷酸序列及推导的一级氨基酸序列。该分子在结构、抗原性和分子水平上与人类病毒的H1血凝素相似,但序列同源性差异表明它们之间近期没有发生血凝素遗传信息的转移。

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