从日本猪身上分离出的H1N1型人流感病毒的抗原性和基因特征。

Antigenic and genetic characteristics of H1N1 human influenza virus isolated from pigs in Japan.

作者信息

Katsuda K, Sato S, Shirahata T, Lindstrom S, Nerome R, Ishida M, Nerome K, Goto H

机构信息

Department of Veterinary Microbiology, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.

出版信息

J Gen Virol. 1995 May;76 ( Pt 5):1247-9. doi: 10.1099/0022-1317-76-5-1247.

DOI:10.1099/0022-1317-76-5-1247

PMID:7730809

Abstract

Two strains of influenza A virus were isolated from pigs in northern Japan in 1992. Serological tests showed that the haemagglutinin (HA) and neuraminidase (NA) antigens were more closely related to those of recent human H1N1 viruses than to those of swine H1N1 viruses. The HA and NA genes of isolate A/sw/Obihiro/5/92 were shown to be closely related to those of current human H1N1 viruses. Evolutionary trees constructed from nucleotide sequences showed that the HA and NA genes of A/sw/Obihiro/5/92 were apparently on a branch cluster containing human strains isolated between 1990 and 1992.

摘要

1992年，从日本北部的猪身上分离出两株甲型流感病毒。血清学检测表明，血凝素（HA）和神经氨酸酶（NA）抗原与近期人类H1N1病毒的抗原关系比与猪H1N1病毒的抗原关系更为密切。分离株A/sw/Obihiro/5/92的HA和NA基因显示与当前人类H1N1病毒的基因密切相关。根据核苷酸序列构建的进化树表明，A/sw/Obihiro/5/92的HA和NA基因明显位于一个分支簇上，该分支簇包含1990年至1992年期间分离出的人类毒株。