Diagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, Michigan State University, 4125 Beaumont Road, Lansing, MI 48910, USA.
Vet Pathol. 2012 Sep;49(5):846-51. doi: 10.1177/0300985811432352. Epub 2012 Feb 3.
Cutaneous lymphoma is a common skin neoplasm of pet rabbits in Europe but is rarely reported in pet rabbits in North America. These neoplasms have not been previously characterized, nor has the cause for the apparent predilection for cutaneous lymphoma in European pet rabbits compared with North American pet rabbits been investigated. In this retrospective study, the authors morphologically and immunohistochemically characterized 25 cutaneous lymphomas in European pet rabbits according to the World Health Organization classification. Tumors were classified as diffuse large B cell lymphomas, with 14 lymphomas exhibiting a centroblastic/centrocytic subtype and 11 tumors exhibiting a T cell-rich B cell subtype. To investigate a potential viral etiology of these lymphomas, 3 diffuse large B cell and 3 T cell-rich B cell lymphomas were evaluated by polymerase chain reaction for retroviral and herpesviral genes. Neither virus was detected. In contrast to other domestic animals, cutaneous lymphomas in European pet rabbits were highly pleomorphic and frequently contained multinucleated giant cells. Unexpectedly, the second most common subtype was T cell-rich B cell lymphoma, a subtype that is rare in species other than horses. Based on a limited number of samples, there was no support for a viral etiology that would explain the higher incidence of lymphoma in European pet rabbits compared with American pet rabbits. Further investigation into genetic and extrinsic factors associated with the development of these tumors is warranted.
皮肤淋巴瘤是欧洲宠物兔常见的皮肤肿瘤，但在北美的宠物兔中很少报道。这些肿瘤以前没有被描述过，也没有研究过为什么欧洲宠物兔比北美宠物兔更容易出现皮肤淋巴瘤。在这项回顾性研究中，作者根据世界卫生组织的分类，对 25 例欧洲宠物兔的皮肤淋巴瘤进行了形态学和免疫组织化学特征分析。肿瘤被分类为弥漫性大 B 细胞淋巴瘤，其中 14 例为中心母细胞/中心细胞亚型，11 例为 T 细胞丰富的 B 细胞亚型。为了研究这些淋巴瘤的潜在病毒病因，用聚合酶链反应对 3 例弥漫性大 B 细胞淋巴瘤和 3 例 T 细胞丰富的 B 细胞淋巴瘤进行了逆转录病毒和疱疹病毒基因检测。两种病毒均未检测到。与其他家畜不同，欧洲宠物兔的皮肤淋巴瘤高度多形性，常含有多核巨细胞。出乎意料的是，第二常见的亚型是 T 细胞丰富的 B 细胞淋巴瘤，这种亚型在马以外的其他物种中很少见。基于有限的样本，没有支持病毒病因的证据可以解释欧洲宠物兔比美国宠物兔淋巴瘤发病率更高的原因。需要进一步研究与这些肿瘤发生相关的遗传和外在因素。
