Department of Psychology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):1878-82. doi: 10.1073/pnas.1120972109. Epub 2012 Jan 23.
Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.
研究一直证明，社会关系会影响身体健康，这种联系可能暗示着系统性炎症。我们研究了日常社会互动是否可以预测促炎细胞因子 IL-6 和肿瘤坏死因子-α 的可溶性受体 (sTNFαRII) 的水平及其对社会应激源的反应。122 名健康的年轻成年人连续 8 天完成了日常日记，记录了积极、消极和竞争的社会互动。然后，参与者参与了实验室应激挑战，并在基线和应激后 25-80 分钟从口腔黏膜渗出液中收集了 IL-6 和 sTNFαRII。消极的社会互动预测了基线时 sTNFαRII 的升高，以及应激后 25 分钟时的 IL-6 和 sTNFαRII，以及 sTNFαRII 的总输出。竞争的社会互动预测了基线时 IL-6 和 sTNFαRII 以及两种细胞因子总输出的升高。这些发现表明，消极和竞争的日常社会互动与促炎细胞因子活性升高有前瞻性关联。
