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固醇调节元件结合蛋白（SREBP）在鸡中的作用。

Effects of sterol regulatory element-binding protein (SREBP) in chickens.

机构信息

Department of Animal Science, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

出版信息

Lipids Health Dis. 2012 Feb 6;11:20. doi: 10.1186/1476-511X-11-20.

DOI:10.1186/1476-511X-11-20
PMID:22309629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3305589/
Abstract

Sterol regulatory element binding protein- 1 and -2 (SREBP-1 and -2) are key transcription factors involved in the biosynthesis of cholesterol and fatty acids. The SREBP have mostly been studied in rodents in which lipogenesis is regulated in both liver and adipose tissue. There is, though, a paucity of information on birds, in which lipogenesis occurs essentially in the liver as in humans. Since a prelude to the investigation of the role of SREBP in lipid metabolism regulation in chicken, we review Size and Tissue expression Pattern of SREBP and role of this protein in chickens.

摘要

固醇调节元件结合蛋白-1 和 -2（SREBP-1 和 -2）是参与胆固醇和脂肪酸生物合成的关键转录因子。SREBP 主要在啮齿动物中进行研究，其中肝脏和脂肪组织中的脂肪生成受到调节。然而，关于鸟类的信息很少，鸟类的脂肪生成主要发生在肝脏中，就像人类一样。由于研究 SREBP 在鸡脂质代谢调节中的作用的前奏，我们回顾了 SREBP 的大小和组织表达模式以及该蛋白在鸡中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/e9aed843e0b4/1476-511X-11-20-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/a311fcac6e26/1476-511X-11-20-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/97c1f1ec4bf6/1476-511X-11-20-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/e9aed843e0b4/1476-511X-11-20-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/a311fcac6e26/1476-511X-11-20-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/97c1f1ec4bf6/1476-511X-11-20-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f6a/3305589/e9aed843e0b4/1476-511X-11-20-3.jpg

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The SREBP pathway--insights from Insigs and insects.固醇调节元件结合蛋白（SREBP）途径——来自胰岛素诱导基因（Insigs）和昆虫的见解
mA mRNA Methylation Was Associated With Gene Expression and Lipid Metabolism in Liver of Broilers Under Lipopolysaccharide Stimulation.脂多糖刺激下肉鸡肝脏中 mA mRNA 甲基化与基因表达及脂质代谢相关
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Effects of lycopene on abdominal fat deposition, serum lipids levels and hepatic lipid metabolism-related enzymes in broiler chickens.番茄红素对肉鸡腹部脂肪沉积、血脂水平及肝脏脂质代谢相关酶的影响。
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Maternal betaine supplementation decreases hepatic cholesterol deposition in chicken offspring with epigenetic modulation of SREBP2 and CYP7A1 genes.母代甜菜碱补充可通过表观遗传调控 SREBP2 和 CYP7A1 基因减少子代鸡肝脏胆固醇沉积。
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