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[危重症患者特殊营养与代谢支持指南。更新版。西班牙重症监护医学与冠心病监护病房学会-西班牙肠外与肠内营养学会(SEMICYUC-SENPE)共识:急性肾衰竭]

[Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): acute renal failure].

作者信息

López Martínez J, Sánchez-Izquierdo Riera J A, Jiménez Jiménez F J

机构信息

Hospital Universitario Severo Ochoa, Madrid, España.

出版信息

Med Intensiva. 2011 Nov;35 Suppl 1:22-7. doi: 10.1016/S0210-5691(11)70005-5.

Abstract

Nutritional support in acute renal failure must take into account the patient's catabolism and the treatment of the renal failure. Hypermetabolic failure is common in these patients, requiring continuous renal replacement therapy or daily hemodialysis. In patients with normal catabolism (urea nitrogen below 10 g/day) and preserved diuresis, conservative treatment can be attempted. In these patients, relatively hypoproteic nutritional support is essential, using proteins with high biological value and limiting fluid and electrolyte intake according to the patient's individual requirements. Micronutrient intake should be adjusted, the only buffering agent used being bicarbonate. Limitations on fluid, electrolyte and nitrogen intake no longer apply when extrarenal clearance techniques are used but intake of these substances should be modified according to the type of clearance. Depending on their hemofiltration flow, continuous renal replacement systems require high daily nitrogen intake, which can sometimes reach 2.5 g protein/kg. The amount of volume replacement can induce energy overload and therefore the use of glucose-free replacement fluids and glucose-free dialysis or a glucose concentration of 1 g/L, with bicarbonate as a buffer, is recommended. Monitoring of electrolyte levels (especially those of phosphorus, potassium and magnesium) and of micronutrients is essential and administration of these substances should be individually-tailored.

摘要

急性肾衰竭的营养支持必须考虑患者的分解代谢情况以及肾衰竭的治疗。这些患者常出现高代谢性衰竭,需要持续肾脏替代治疗或每日血液透析。对于分解代谢正常(尿素氮低于10克/天)且仍有尿量的患者,可尝试保守治疗。在这些患者中,相对低蛋白的营养支持至关重要,应使用生物价值高的蛋白质,并根据患者个体需求限制液体和电解质摄入。应调整微量营养素的摄入量,唯一使用的缓冲剂为碳酸氢盐。当采用肾外清除技术时,不再限制液体、电解质和氮的摄入,但这些物质的摄入量应根据清除类型进行调整。根据其血液滤过流量,持续肾脏替代系统需要较高的每日氮摄入量,有时可达2.5克蛋白质/千克。补液量可能会导致能量过载,因此建议使用无糖置换液和无糖透析液,或葡萄糖浓度为1克/升的透析液,并以碳酸氢盐作为缓冲剂。监测电解质水平(尤其是磷、钾和镁的水平)以及微量营养素至关重要,这些物质的给药应个体化定制。

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