Vaquerizo Alonso C, Grau Carmona T, Juan Díaz M
Hospital Universitario de Fuenlabrada, Madrid, España.
Med Intensiva. 2011 Nov;35 Suppl 1:48-52. doi: 10.1016/S0210-5691(11)70010-9.
Hyperglycemia is one of the main metabolic disturbances in critically-ill patients and is associated with increased morbidity and mortality. Consequently, blood glucose levels must be safely and effectively controlled, that is, maintained within a normal range, avoiding hypoglycemia on the one hand and elevated glucose concentrations on the other. To accomplish this aim, insulin is often required, avoiding protocols designed to achieve tight glycemic control. To prevent hyperglycemia and its associated complications, energy intake should be adjusted to patients' requirements, avoiding overnutrition and excessive glucose intake. Protein intake should be adjusted to the degree of metabolic stress. Whenever patients require artificial feeding, the enteral route, if not contraindicated, should be used since parenteral nutrition is associated with a higher frequency of hyperglycemia and greater insulin requirements. Enteral nutrition should be administered early, preferably within the first 24 hours of admission to the intensive care unit, after hemodynamic stabilization. Specific diets for hyperglycemia, containing low glycemic index carbohydrates and fibre and enriched with monounsaturated fatty acids, can achieve good glycemic control with lower insulin requirements.
高血糖是重症患者主要的代谢紊乱之一,与发病率和死亡率增加相关。因此,必须安全有效地控制血糖水平,即维持在正常范围内,一方面避免低血糖,另一方面避免血糖浓度升高。为实现这一目标,通常需要使用胰岛素,避免采用旨在实现严格血糖控制的方案。为预防高血糖及其相关并发症,能量摄入应根据患者需求进行调整,避免营养过剩和过多的葡萄糖摄入。蛋白质摄入量应根据代谢应激程度进行调整。只要患者需要人工喂养,若没有禁忌证,应采用肠内途径,因为肠外营养与更高的高血糖发生率和更高的胰岛素需求量相关。肠内营养应尽早给予,最好在入住重症监护病房后的24小时内,待血流动力学稳定后进行。含低血糖指数碳水化合物、纤维且富含单不饱和脂肪酸的高血糖专用饮食,可在较低胰岛素需求量的情况下实现良好的血糖控制。