Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Arch Biochem Biophys. 2012 Jul 1;523(1):30-6. doi: 10.1016/j.abb.2012.01.013. Epub 2012 Jan 31.
Bioactivation of vitamin D(3) involves 25-hydroxylation and subsequent 1α-hydroxylation to produce 1α,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], the active hormone. Six cytochrome P450 enzymes (CYP27A1, CYP2R1, CYP2J2/3, CYP3A4, CYP2D25 and CYP2C11) catalyzing the initial 25-hydroxylation step are reviewed, and their physiological relevance as vitamin D 25-hydroxylases in vivo is discussed.
维生素 D(3) 的生物活化涉及 25-羟化作用和随后的 1α-羟化作用，以产生 1α,25-二羟基维生素 D(3) [1,25(OH)(2)D(3)]，这是一种活性激素。综述了催化初始 25-羟化步骤的六种细胞色素 P450 酶（CYP27A1、CYP2R1、CYP2J2/3、CYP3A4、CYP2D25 和 CYP2C11），并讨论了它们作为体内维生素 D 25-羟化酶的生理相关性。
