Cruzado Josep M, Bestard Oriol, Grinyó Josep M
Contrib Nephrol. 2012;176:108-116. doi: 10.1159/000332389. Epub 2012 Jan 30.
Hepatitis C virus (HCV) infection is associated with some extrahepatic complications, like diabetes, cryoglobulinemia, and membranoproliferative glomerulonephritis. Each of these complications has important implications in the renal allograft recipient. Hence, HCV infection is strongly associated with a lower patient and graft survival in renal transplantation. The increased risk of death in HCV-infected renal allograft recipients has been attributed to cardiovascular mortality, linked someway to the insulin resistance and high risk of new-onset diabetes, rather than to the progression of HCV-related liver disease. On the other hand, graft survival is hampered by the occurrence of de novo HCV-related glomerulonephritis and the higher risk of chronic humoral rejection in this population.
丙型肝炎病毒（HCV）感染与一些肝外并发症相关，如糖尿病、冷球蛋白血症和膜增生性肾小球肾炎。这些并发症中的每一种在肾移植受者中都有重要影响。因此，HCV感染与肾移植中患者和移植物存活率较低密切相关。HCV感染的肾移植受者死亡风险增加归因于心血管死亡率，这在某种程度上与胰岛素抵抗和新发糖尿病的高风险有关，而非HCV相关肝病的进展。另一方面，该人群中出现新发HCV相关肾小球肾炎以及慢性体液排斥反应的较高风险阻碍了移植物存活。
