Nephro-Urology Unit, UCL Institute of Child Health, 30 Guilford Street, London WC1N 1EH, UK.
Nat Rev Nephrol. 2012 Feb 7;8(4):244-50. doi: 10.1038/nrneph.2011.219.
Chronic kidney disease is characterized by progressive loss of the renal microvasculature, which leads to local areas of hypoxia and induction of profibrotic responses, scarring and deterioration of renal function. Revascularization alone might be sufficient to restore kidney function and regenerate the structure of the diseased kidney. For revascularization to be successful, however, the underlying disease process needs to be halted or alleviated and there must remain a sufficient number of surviving nephron units that can serve as a scaffold for kidney regeneration. This Perspectives article describes how revascularization might be achieved using vascular growth factors or adoptive transfer of endothelial progenitor cells and provides a brief outline of the studies performed to date. An overview of how therapeutic strategies targeting the microvasculature could be enhanced in the future is also presented.
慢性肾脏病的特征是肾脏微血管进行性丧失，导致局部缺氧和诱导纤维增生反应、瘢痕形成和肾功能恶化。单独的血管再通可能足以恢复肾功能并再生病变肾脏的结构。然而，为了使血管再通成功，需要停止或缓解潜在的疾病进程，并且必须有足够数量的存活的肾单位作为肾脏再生的支架。本文观点描述了如何使用血管生长因子或内皮祖细胞的过继转移来实现血管再通，并简要概述了迄今为止进行的研究。还概述了如何在未来增强针对微血管的治疗策略。
