两种不同的重组乙肝疫苗免疫健康成年人后诱导的乙肝表面抗原血症
Induced HBs antigenemia in healthy adults after immunization with two different hepatitis B recombinant vaccines.
作者信息
Ziaee Masoud, Saádatjoo Alireza, Mohamadpour Malihe, Namaei Mohammad Hasan
机构信息
Infectious Disease Ward, Birjand University of Medical Sciences, Birjand, IR Iran.
出版信息
Hepat Mon. 2010 Fall;10(4):298-301. Epub 2010 Dec 1.
BACKGROUND AND AIMS
Currently, vaccination is the most effective protective tool against hepatitis B virus infection. Some studies have shown that positive results for a hepatitis B virus surface antigen (HBsAg) test may be seen after vaccination.
MATERIALS AND METHODS
In this clinical trial study, 62 healthy adult volunteers were randomly assigned to receive either the Engerix-B or the Hepavax-Gene hepatitis B recombinant vaccine. Blood samples were drawn 1, 3, and 5 days after vaccination and were tested for HBsAg using two different ELISA kits (Behring and Mega).
RESULTS
HBsAg was positive in 5, 3, and 2 participants of the Engerix-B group in the 1st, 3rd, and 5th days after vaccination, respectively, using the Behring ELISA kit the test was positive in only one subject in the Hepavax-Gene group, on the 5th day after vaccination. No positive result was seen in any groups when the Mega ELISA kit was used to test the specimens.
CONCLUSIONS
Our results showed transient HBsAg antigenemia after vaccination against hepatitis B. This condition depends on the type of vaccine and the HBsAg diagnostic test.
背景与目的
目前，接种疫苗是预防乙型肝炎病毒感染最有效的防护手段。一些研究表明，接种疫苗后可能会出现乙型肝炎病毒表面抗原（HBsAg）检测呈阳性的结果。
材料与方法
在这项临床试验研究中，62名健康成年志愿者被随机分配接受安在时（Engerix-B）或重组酵母乙型肝炎疫苗（Hepavax-Gene）。在接种疫苗后的第1、3和5天采集血样，并用两种不同的酶联免疫吸附测定试剂盒（贝林和梅加）检测HBsAg。
结果
使用贝林酶联免疫吸附测定试剂盒时，安在时组分别在接种疫苗后的第1、3和5天有5名、3名和2名参与者的HBsAg呈阳性；在接种疫苗后的第5天，重组酵母乙型肝炎疫苗组只有1名受试者检测呈阳性。当使用梅加酶联免疫吸附测定试剂盒检测样本时，任何组均未出现阳性结果。
结论
我们的结果显示，接种乙型肝炎疫苗后会出现短暂的HBsAg抗原血症。这种情况取决于疫苗类型和HBsAg诊断检测方法。
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