Mannath Jayan, Banks Matthew
Department of Gastroenterology, University College London Hospitals NHS Trust, 235 Euston Road, London, NW1 2BU United Kingdom.
F1000 Med Rep. 2012;4:3. doi: 10.3410/M4-3. Epub 2012 Feb 1.
Endoscopic imaging is in part responsible for the recent drop in deaths from gastrointestinal cancers and also for detecting pre-cancerous and non-cancerous conditions and allowing them to be treated effectively, although techniques are far from perfect. Endoscopic imaging has evolved considerably from fiber optic systems 50 years ago to high resolution and high definition systems used at present. Moreover, image enhancement using filters and processors has led to the technique of 'electronic chromoendoscopy' to visualize mucosal blood vessels and surface pit patterns clearly. Magnification by optical zoom or confocal laser microscopy has enabled real time diagnosis and 'virtual histology'. These techniques have contributed to the early detection, assessment and treatment of various gastrointestinal pathologies. The focus of future research is directed towards molecular targeted imaging.
内镜成像在一定程度上促成了近期胃肠癌死亡率的下降,还能检测癌前病变和非癌性病变并使其得到有效治疗,尽管技术还远非完美。内镜成像已从50年前的光纤系统大幅发展到目前使用的高分辨率和高清晰度系统。此外,使用滤光器和处理器进行图像增强催生了“电子染色内镜检查”技术,能够清晰地观察黏膜血管和表面凹坑图案。通过光学变焦或共聚焦激光显微镜放大,实现了实时诊断和“虚拟组织学”。这些技术有助于各种胃肠疾病的早期检测、评估和治疗。未来研究的重点是分子靶向成像。