Ziganshin A U
Vestn Ross Akad Med Nauk. 2011(11):32-8.
P2-receptors are widespread in animal and human organs and tissues. Therefore, they attract much attention as potential targets of new drugs. This article presents in brief characteristics of P2 receptors and reviews the author's search for new antagonists of P2-receptors as well as his studies on the role of ectonucleotidases and unique temperature-dependence of P2 receptor activity. In addition, the presence and functional activity of P2 receptors in human uterus, fallopian tubes, heart and blood vessels are described. The possible physiological and pathophysiological role of P2 receptors in these tissues, as well as prospects for the development of drugs acting via P2 receptors is discussed.
P2受体广泛存在于动物和人体的器官及组织中。因此，它们作为新药的潜在靶点备受关注。本文简要介绍了P2受体的特性，并综述了作者对P2受体新型拮抗剂的探索，以及他对外核苷酸酶的作用和P2受体活性独特温度依赖性的研究。此外，还描述了P2受体在人子宫、输卵管、心脏和血管中的存在及功能活性。本文讨论了P2受体在这些组织中可能的生理和病理生理作用，以及通过P2受体发挥作用的药物的开发前景。
