Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Herbert Irving Comprehensive Cancer Center, Division of Hematology-Oncology, Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY 10032, USA.
Trends Cancer. 2021 Aug;7(8):731-750. doi: 10.1016/j.trecan.2021.04.008. Epub 2021 May 29.
ATP hydrolysis and downstream signaling pathways in the extracellular space have a major impact upon tumor progression and metastasis. The complexity and interdependence of various cell types in the extracellular space have been increasingly appreciated in recent years. With increased awareness of the importance of this signaling pathway in the pathogenic development and progression of malignancies, there has been attention to therapeutic strategies targeting extracellular adenosine metabolism and signaling. This review summarizes the molecular and physiologic roles of extracellular ATP and adenosine in normal and disease states, and potential therapeutic applications.
细胞外空间中的 ATP 水解和下游信号通路对肿瘤的进展和转移有重大影响。近年来，人们越来越认识到细胞外空间中各种细胞类型的复杂性和相互依存性。由于认识到这种信号通路在恶性肿瘤的发病机制和进展中的重要性，人们开始关注针对细胞外腺苷代谢和信号的治疗策略。本文综述了细胞外 ATP 和腺苷在正常和疾病状态下的分子和生理作用以及潜在的治疗应用。
