Laboratório de Toxoplasmose e outras Protozoosis, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Laboratório de Toxoplasmose e outras Protozoosis, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; Programa de pós-graduação em Ciências e Biotecnologia, Instituto de Biologia - UFF, Niterói, Brazil.
Fitoterapia. 2020 Oct;146:104709. doi: 10.1016/j.fitote.2020.104709. Epub 2020 Aug 20.
In recent years, interest in the research of P2 receptor (P2R)-mediated responses has grown significantly due to the recognition of the involvement of these receptors in various physiological and pathological processes. Despite all the progress made in the functional characterization of P2Rs, purinergic signaling research is still limited by the lack of selective or efficient ligands for different receptor subtypes. In this sense, several molecules have been tested towards these receptors as agonists or antagonists. Historically, natural products have always been sources of new bioactive substances for diverse purposes. However, compared to synthetic molecules, the number of natural products assessed for P2R ligands is still low. In this review, we present examples of studies that demonstrated plant natural products acting directly on P2R and modulating their functionality. In some cases, we highlight that the pharmacological activity previously described for the original organism could be correlated to an agonist or antagonist activity of a specific natural product on these receptors. These examples reinforce the need for more studies to investigate the pharmacological potential of new or known natural compounds targeting P2 receptors.
近年来，由于认识到这些受体参与各种生理和病理过程，人们对 P2 受体 (P2R) 介导的反应的研究产生了浓厚的兴趣。尽管在 P2R 的功能特征描述方面取得了所有进展，但由于缺乏针对不同受体亚型的选择性或有效的配体，嘌呤能信号转导研究仍然受到限制。在这种情况下，已经有几种分子被测试为这些受体的激动剂或拮抗剂。从历史上看，天然产物一直是各种用途的新生物活性物质的来源。然而，与合成分子相比，评估用于 P2R 配体的天然产物数量仍然较少。在这篇综述中，我们介绍了一些研究实例，这些实例表明植物天然产物直接作用于 P2R 并调节其功能。在某些情况下，我们强调先前为原始生物体描述的药理活性可能与这些受体上特定天然产物的激动剂或拮抗剂活性相关。这些例子强调了需要进行更多的研究来调查针对 P2 受体的新的或已知天然化合物的药理潜力。
