Wright Charles T, Goudy Steven L
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Ann Otol Rhinol Laryngol. 2012 Jan;121(1):57-60. doi: 10.1177/000348941212100110.
We undertook to characterize the natural course and duration of stridor and other symptoms associated with laryngomalacia and determine the need for surgical intervention.
A retrospective observational study was performed at a tertiary children's hospital of 120 consecutive cases of congenital laryngomalacia diagnosed and treated by the senior author between July 2005 and June 2009. The patients' symptoms, associated symptoms, and required interventions were recorded.
In 115 cases that were managed without surgery, stridor resolved at a mean patient age of 7.6 months. Five patients (4.2%) required supraglottoplasty to resolve their airway obstruction. The patients who required surgery presented emergently to the hospital 80% of the time, and at a younger mean age (45 days) than did patients who did not require surgery (95 days; p = 0.13); these findings suggest the severe nature of their symptoms. Presenting symptoms of dyspnea or accessory muscle use, feeding difficulties, apnea, cyanosis, oxygen desaturation, and failure to thrive were significantly associated with the requirement for operative intervention (all p values less than 0.02). Nonoperative management included placement of a nasogastric tube due to aspiration in 3 patients.
The stridor resolved at an average age of 7.6 months of age in patients with laryngomalacia managed without surgery. A young age at presentation and emergent evaluation in the hospital are associated with a higher degree of symptom severity and a higher rate of surgical intervention. Surgical intervention was necessary to treat laryngomalacia in 4.2% of patients in this study population.
我们旨在描述与喉软化相关的喘鸣及其他症状的自然病程和持续时间,并确定手术干预的必要性。
在一家三级儿童医院进行了一项回顾性观察研究,纳入了2005年7月至2009年6月期间由资深作者诊断并治疗的120例先天性喉软化连续病例。记录患者的症状、相关症状及所需干预措施。
在115例未经手术治疗的病例中,喘鸣在患者平均年龄7.6个月时消失。5例患者(4.2%)需要进行声门上成形术以解除气道梗阻。需要手术的患者80%是紧急入院,且平均年龄(45天)比不需要手术的患者(95天)小(p = 0.13);这些发现提示了他们症状的严重性。出现呼吸困难或使用辅助肌、喂养困难、呼吸暂停、发绀、氧饱和度下降及生长发育迟缓等症状与手术干预的需求显著相关(所有p值均小于0.02)。非手术治疗包括3例因误吸而放置鼻胃管。
未经手术治疗的喉软化患者,喘鸣平均在7.6个月龄时消失。就诊时年龄小且紧急入院评估与症状严重程度较高及手术干预率较高相关。在本研究人群中,4.2%的患者需要手术干预来治疗喉软化。