Fagbohun T R, Odufuwa K T
Department of Physiology, Faculty of Basic Medical Sciences,Olabisi Onabanjo University, Ogun State.
Niger J Physiol Sci. 2010 Nov 25;25(1):87-90.
Anacardium occidentale Leave (Anacardiaceae), a plant natively grown in wastelands in Africa is used as a folk remedy for diabetes mellitus. Previous studies, reported the hypoglycemic effect of the aqueous leaf extract of A. occidentale in diabetic rats and its prophylactic activity against the diabetogenic action of streptozotocin This study evaluated the hypoglycemic effect of a methanolic extract of streptozotocin leaves and its fractions in Alloxan-induced diabetic rats in comparison to Tolbutamide, a reference drug. For moderately diabetic rat, A. occidentale caused a 79.2 % change over 4 hours and Tolbutamide caused a 63.1 % change over this same time period. When the rat were considered to be severely diabetic, the A. occidentale decreased the blood glucose levels by 20.8% change over four hours and the mean percent change over 4 hours for Tolbutamide was 47.63%. These values were not considered significant. So the same conclusion can be made about the efficacy of A. occidentale, when compared to the reference drug, Tolbutamide. These results that show that A. occidentale has a similar ability compared with Tolbutamide to lower blood glucose levels.
腰果叶（漆树科）是一种原产于非洲荒地的植物，被用作糖尿病的民间疗法。先前的研究报道了腰果叶水提取物对糖尿病大鼠的降血糖作用及其对链脲佐菌素致糖尿病作用的预防活性。本研究评估了腰果叶甲醇提取物及其馏分对四氧嘧啶诱导的糖尿病大鼠的降血糖作用，并与对照药物甲苯磺丁脲进行了比较。对于中度糖尿病大鼠，腰果叶在4小时内导致血糖变化79.2%，而甲苯磺丁脲在同一时间段内导致血糖变化63.1%。当大鼠被认为患有严重糖尿病时，腰果叶在4小时内使血糖水平降低了20.8%的变化，甲苯磺丁脲在4小时内的平均变化百分比为47.63%。这些值被认为不显著。因此，与对照药物甲苯磺丁脲相比，关于腰果叶的疗效可以得出相同的结论。这些结果表明，与甲苯磺丁脲相比，腰果叶具有类似的降低血糖水平的能力。
