Vecchiarelli A, Monari C
Department of Experimental Medicine and Biochemical Sciences, Microbiology Section, University of Perugia, Via del Giochetto, 06126, Perugia, Italy,
Mycopathologia. 2012 Feb 8. doi: 10.1007/s11046-011-9513-8.
The capsule is generally considered one of the more powerful virulence factors of microorganisms, driving research in the field of microbial pathogenesis and in the development of vaccines. Cryptococcus neoformans is unique among the most common human fungal pathogens in that it possesses a complex polysaccharide capsule. This review focuses on the Cryptococcus neoformans capsule from the viewpoint of fungal pathogenesis, and the effective immune response target of the capsule's main component, glucuronoxylomannan.
荚膜通常被认为是微生物更强大的毒力因子之一，推动了微生物发病机制领域的研究以及疫苗的开发。新型隐球菌在最常见的人类真菌病原体中是独特的，因为它具有复杂的多糖荚膜。本综述从真菌发病机制的角度聚焦于新型隐球菌荚膜，以及荚膜主要成分葡糖醛酸木聚糖的有效免疫反应靶点。
