清除幽门螺杆菌对学龄儿童生长的长期影响。
Long-term effects of clearing Helicobacter pylori on growth in school-age children.
机构信息
Division of Gastroenterology, Hepatology and Nutrition, Vanderbilt University Medical Center, Nashville, TN, USA.
出版信息
Pediatr Infect Dis J. 2012 Mar;31(3):263-6. doi: 10.1097/INF.0b013e3182443fec.
BACKGROUND
A new Helicobacter pylori infection affects growth velocity negatively, and clearing the infection produces a small significant rebound, but it is not known whether height and weight in children are impacted over the long term.
METHODS
We investigated 295 school-age children followed in 2 cohorts, treated (150) and untreated (145), from 2004 for 3.7 years with 1105 child-years of observation. Follow-up intervals were 3 months for anthropometry measurements and 6 months for H. pylori status ascertained by urea breath test. Height in centimeters and weight in kilograms were analyzed using growth models.
RESULTS
A multivariate mixed model that adjusted for age, sex, father's education, and number of siblings found no significant differences in height or weight at baseline by H. pylori status. The same model showed a significant impact of clearing H. pylori across time, with increasing significant differences in average height and weight as the follow-up progressed.
CONCLUSIONS
Children who were always negative or who cleared the infection grew significantly faster than those who stayed positive after adjusting for other covariates. This study suggests that school-age children's growth benefits from being treated for H. pylori infection.
背景
新的幽门螺杆菌感染会对生长速度产生负面影响，清除感染会产生微小但显著的反弹，但目前尚不清楚儿童的身高和体重是否会受到长期影响。
方法
我们调查了 295 名学龄儿童，他们分别来自 2004 年开始的 2 个队列，其中 150 名接受了治疗，145 名未接受治疗，随访时间为 3.7 年，共观察了 1105 个儿童年。随访间隔为 3 个月进行人体测量，6 个月进行尿素呼气试验以确定 H. pylori 状态。使用生长模型分析身高（厘米）和体重（公斤）。
结果
多变量混合模型调整了年龄、性别、父亲的教育程度和兄弟姐妹数量，发现 H. pylori 状态与身高或体重在基线时无显著差异。同样的模型显示，清除 H. pylori 对时间有显著影响，随着随访的进行，平均身高和体重的差异显著增加。
结论
在调整了其他协变量后，始终为阴性或清除了感染的儿童的生长速度明显快于持续阳性的儿童。本研究表明，治疗儿童的 H. pylori 感染有助于其生长。
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