Yoshida Toshiyuki, Washio Kaoru, Iwata Takanori, Okano Teruo, Ishikawa Isao
Institute of Advanced Biomedical Engineering and Science, Tokyo Women's Medical University, 8-1 Kawata-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Int J Dent. 2012;2012:307024. doi: 10.1155/2012/307024. Epub 2012 Jan 16.
It has been shown that stem cell transplantation can regenerate periodontal tissue, and several clinical trials involving transplantation of stem cells into human patients have already begun or are in preparation. However, stem cell transplantation therapy is a new technology, and the events following transplantation are poorly understood. Several studies have reported side effects and potential risks associated with stem cell transplantation therapy. To protect patients from such risks, governments have placed regulations on stem cell transplantation therapies. It is important for the clinicians to understand the relevant risks and governmental regulations. This paper describes the ongoing clinical studies, basic research, risks, and governmental controls related to stem cell transplantation therapy. Then, one clinical study is introduced as an example of a government-approved periodontal cell transplantation therapy.
研究表明，干细胞移植可使牙周组织再生，目前已有多项将干细胞移植到人类患者体内的临床试验已经开始或正在筹备中。然而，干细胞移植疗法是一项新技术，移植后的情况尚不清楚。多项研究报告了与干细胞移植疗法相关的副作用和潜在风险。为保护患者免受此类风险，政府已对干细胞移植疗法进行监管。临床医生了解相关风险和政府规定非常重要。本文介绍了与干细胞移植疗法相关的正在进行的临床研究、基础研究、风险及政府管控措施。随后，引入一项临床研究作为政府批准的牙周细胞移植疗法的实例。
