Koren G, Lau A, Kenyon C F, Kroppert D, Klein J
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ontario.
J Toxicol Clin Toxicol. 1990;28(3):371-8. doi: 10.3109/15563659008994438.
Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death (1). We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.
两性霉素是治疗婴幼儿真菌感染的首选药物。按推荐剂量使用时，两性霉素治疗会伴随高比率的不良反应，包括肾毒性、肝毒性、白细胞、血小板和血红蛋白减少、寒战、发热甚至死亡（1）。我们报告了一例涉及一名新生儿的病例，该新生儿在三天内接触了50倍过量的两性霉素。
