Schöllnberger H, Stewart R D, Mitchel R E J
Department of Molecular Biology, University of Salzburg, Hellbrunnerstr. 34, A-5020 Salzburg, Austria,
Int J Low Radiat. 2006;3(2/3):135-142. doi: 10.1504/IJLR.2006.012012.
In vitro studies show that protective tumour-reducing effects occur for low dose rates (mGy per minute). To account for these phenomena, we have previously developed stochastic and deterministic multi-stage cancer models that include radiation-induced adaptations in DNA repair processes and radical scavenging. Here, these models are extended to account for the induction of radioprotective mechanisms for low doses of low LET radiation delivered at high dose rates. Cellular adaptations in DNA repair are related to temporal changes in the amount of DNA damage in a cell. The combined effects of endogenous DNA damage, background radiation and artificial irradiation are considered.
体外研究表明，低剂量率（每分钟毫戈瑞）会产生保护性的肿瘤缩小效应。为了解释这些现象，我们之前开发了随机和确定性多阶段癌症模型，这些模型包括辐射诱导的DNA修复过程适应和自由基清除。在此，这些模型得到扩展，以解释高剂量率下低LET辐射低剂量诱导的辐射防护机制。DNA修复中的细胞适应与细胞内DNA损伤量的时间变化有关。考虑了内源性DNA损伤、背景辐射和人工辐射的综合影响。
