The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine, Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
J Dent Res. 2012 Aug;91(8):736-44. doi: 10.1177/0022034511435260. Epub 2012 Feb 8.
Since the discovery of osteoinduction in the early 20th century, innovative biomaterials with osteoinductive potential have emerged. Over the last 50 years, however, our ability to describe biological phenomena accurately has been improved dramatically by advancements in cell and molecular biology. The aim of this review is to divide the osteoinduction phenomenon into 3 principles: (1) mesenchymal cell recruitment, (2) mesenchymal differentiation to bone-forming osteoblasts, and (3) ectopic bone formation in vivo. Furthermore, this review formulates guidelines for in vitro and in vivo experimental testing for accurately defining new biomaterials as osteoinductive. The use of growth factors with osteoinductive potential in periodontal and oral surgery is discussed. These concepts and guidelines aim to guide the future direction of emerging biomaterials in bone regeneration.
自 20 世纪初发现骨诱导以来，具有骨诱导潜力的创新生物材料不断涌现。然而，在过去的 50 年中，细胞和分子生物学的进步极大地提高了我们准确描述生物学现象的能力。本综述的目的是将骨诱导现象分为 3 个原则：（1）间充质细胞募集，（2）间充质向成骨细胞的分化，以及（3）体内异位骨形成。此外，本综述还制定了体外和体内实验测试的指南，以准确地将新型生物材料定义为骨诱导材料。本文还讨论了具有骨诱导潜力的生长因子在牙周和口腔手术中的应用。这些概念和指南旨在指导骨再生领域新兴生物材料的未来发展方向。
