State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, China.
Sensors (Basel). 2010;10(4):3585-96. doi: 10.3390/s100403585. Epub 2010 Apr 8.
This article provides a novel method of constructing an optical fiber localized surface plasmon resonance (LSPR) biosensor. A gold nanoparticle (NP) assembled film as the sensing layer was built on the polyelectrolyte (PE) multilayer modified sidewall of an unclad optical fiber. By using a trilayer PE structure, we obtained a monodisperse gold NP assembled film. The preparation procedure for this LSPR sensor is simple and time saving. The optical fiber LSPR sensor has higher sensitivity and outstanding reproducibility. The higher anti-interference ability for response to an antibody makes it a promising method in application as a portable immuno-sensor.
本文提出了一种构建光纤局域表面等离子体共振（LSPR）生物传感器的新方法。将金纳米粒子（NP）组装膜作为传感层构建在未涂覆光纤的聚电解质（PE）多层修饰侧壁上。通过使用三层 PE 结构，我们获得了单分散金 NP 组装膜。这种 LSPR 传感器的制备过程简单、省时。光纤 LSPR 传感器具有更高的灵敏度和出色的重现性。对抗体响应的更高抗干扰能力使其成为一种有前途的便携式免疫传感器应用方法。
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