Laboratory of Bioorganic & Medicinal Chemistry, School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, P.R. China.
Curr Med Chem. 2012;19(2):239-80. doi: 10.2174/092986712803414213.
Triazole compounds containing three nitrogen atoms in the five-membered aromatic azole ring are readily able to bind with a variety of enzymes and receptors in biological system via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in triazole-based derivatives as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired. Noticeably, a large number of triazole compounds as clinical drugs or candidates have been frequently employed for the treatment of various types of diseases, which have shown their large development value and wide potential as medicinal agents. This work systematically reviewed the recent researches and developments of the whole range of triazole compounds as medicinal drugs, including antifungal, anticancer, antibacterial, antitubercular, antiviral, anti-inflammatory and analgesic, anticonvulsant, antiparasitic, antidiabetic, anti-obesitic, antihistaminic, anti-neuropathic, antihypertensive as well as other biological activities. The perspectives of the foreseeable future in the research and development of triazole-based compounds as medicinal drugs are also presented. It is hoped that this review will serve as a stimulant for new thoughts in the quest for rational designs of more active and less toxic triazole medicinal drugs.
三唑类化合物含有五元芳香氮唑环中的三个氮原子，能够通过多种非共价相互作用与生物系统中的各种酶和受体结合，从而表现出多种生物活性。三唑类衍生物作为药物的相关研究一直是一个非常活跃的课题，已经取得了许多优异的成果。值得注意的是，大量的三唑类化合物作为临床药物或候选药物被频繁用于治疗各种类型的疾病，这表明它们具有很大的发展价值和作为药物的广泛潜力。这项工作系统地综述了三唑类化合物作为药物的整个范围的最新研究和发展，包括抗真菌、抗癌、抗菌、抗结核、抗病毒、抗炎和镇痛、抗惊厥、抗寄生虫、抗糖尿病、抗肥胖、抗组胺、抗神经病、抗高血压以及其他生物活性。还提出了三唑类化合物作为药物研究和开发的未来展望。希望这篇综述能为寻找更有效、毒性更小的三唑类药物的合理设计提供新的思路。
