Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Thandalam, Chennai, Tamil Nadu, 602105, India.
Curr Top Med Chem. 2024;24(23):2033-2049. doi: 10.2174/0115680266308359240708094001.
Recently, a large number of novel heterocyclic compounds and their derivatives have been synthesized, and studies on their biological functions have been conducted. Even though the triazole moiety of this scaffold appears to be fairly small, many researchers are interested in it because of its biological profile and variety of potential uses. Triazole derivatives have been synthesized and published by various researchers as their important characteristic against various diseases. Several researchers are interested in this scaffold because of its biological profile and wide variety of potential uses, even if its triazole moiety seems to be somewhat less. The derivative of this heterocyclic ring produced various biological activities such as anti-inflammatory, anticonvulsant, hypoglycemic, antitubercular, anxiolytic, antimicrobial, antitumor, and anticancer. The current review article focuses on pharmacological profile associated with triazoles and mainly focuses on structural modification done for various targets, along with a brief description of targets.
最近，大量新型杂环化合物及其衍生物被合成，并对其生物功能进行了研究。尽管该支架的三唑部分似乎相当小，但由于其生物特征和多种潜在用途，许多研究人员对其感兴趣。三唑衍生物已被不同的研究人员合成和发表，因为它们对各种疾病具有重要的特性。一些研究人员对该支架感兴趣，因为它的生物特征和广泛的潜在用途，即使它的三唑部分看起来有点小。该杂环环的衍生物产生了各种生物活性，如抗炎、抗惊厥、降血糖、抗结核、抗焦虑、抗菌、抗肿瘤和抗癌。本文综述了与三唑相关的药理学特征，主要集中于对各种靶点进行的结构修饰，以及靶点的简要描述。
