Southern California Research Center for Alcoholic Liver and Pancreatic Diseases, University of California and Department of Veterans Affairs, Los Angeles, California, USA.
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2(0 2):127-34. doi: 10.1111/j.1440-1746.2011.07013.x.
There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk factors for pancreatic cancer, and uses this information to propose plausible research directions for determining the biological mechanisms mediating the effects of risk factors on the promotion of pancreatic cancer, with a focus on the pancreatic stellate cell.
每年约有 277,000 例新诊断的胰腺癌病例和 266,000 例胰腺癌死亡病例，这表明诊断出的病例中有 96%的死亡率。由于治疗效果不佳，因此需要重点关注预防。本文综述了胰腺癌的流行病学和危险因素，并利用这些信息提出了合理的研究方向，以确定介导危险因素对胰腺癌促进作用的生物学机制，重点是胰腺星状细胞。
