流行病学、风险因素与胰腺癌的促进：星状细胞的作用。
Epidemiology, risk factors, and the promotion of pancreatic cancer: role of the stellate cell.
机构信息
Southern California Research Center for Alcoholic Liver and Pancreatic Diseases, University of California and Department of Veterans Affairs, Los Angeles, California, USA.
出版信息
J Gastroenterol Hepatol. 2012 Mar;27 Suppl 2(0 2):127-34. doi: 10.1111/j.1440-1746.2011.07013.x.
Abstract
There are approximately 277,000 new cases of pancreatic cancer and 266,000 deaths from pancreatic cancer annually, indicating a mortality rate of 96% of the cases diagnosed. Because of the ineffectiveness of therapies, a major emphasis needs to be placed on prevention. This paper reviews the epidemiology and risk factors for pancreatic cancer, and uses this information to propose plausible research directions for determining the biological mechanisms mediating the effects of risk factors on the promotion of pancreatic cancer, with a focus on the pancreatic stellate cell.
摘要
每年约有 277,000 例新诊断的胰腺癌病例和 266,000 例胰腺癌死亡病例，这表明诊断出的病例中有 96%的死亡率。由于治疗效果不佳，因此需要重点关注预防。本文综述了胰腺癌的流行病学和危险因素，并利用这些信息提出了合理的研究方向，以确定介导危险因素对胰腺癌促进作用的生物学机制，重点是胰腺星状细胞。
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本文引用的文献
1
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Carcinogenesis. 2011 Nov;32(11):1689-96. doi: 10.1093/carcin/bgr191. Epub 2011 Aug 22.
2
Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats.维生素 D 可抑制肝星状细胞增殖和表达致纤维化标志物，并可减轻硫代乙酰胺诱导的大鼠肝纤维化。
Gut. 2011 Dec;60(12):1728-37. doi: 10.1136/gut.2010.234666. Epub 2011 Aug 4.
3
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Cancer Res. 2011 May 15;71(10):3453-8. doi: 10.1158/0008-5472.CAN-10-1633. Epub 2011 May 10.
4
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008.2008 年全球癌症负担估计值：GLOBOCAN 2008。
Int J Cancer. 2010 Dec 15;127(12):2893-917. doi: 10.1002/ijc.25516.
5
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J Biol Chem. 2011 Mar 11;286(10):7779-7787. doi: 10.1074/jbc.M110.200063. Epub 2010 Nov 30.
6
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Circ Res. 2010 Jul 9;107(1):56-65. doi: 10.1161/CIRCRESAHA.110.218420. Epub 2010 May 20.
10
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Pancreas. 2010 Jul;39(5):669-74. doi: 10.1097/MPA.0b013e3181ce654d.
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