Department of General and Digestive Surgery, Colorectal Unit, Bellvitge University Hospital, Spain.
Colorectal Dis. 2012 Jul;14(7):e407-12. doi: 10.1111/j.1463-1318.2012.02976.x.
There has been controversy about the presentation and treatment of acute colonic diverticulitis (AD) in young patients. The aim of this observational study was to evaluate the virulence and natural history of AD in three different age groups of patients.
The study was performed on 686 patients with the diagnosis of a first episode of AD admitted between January 1998 and December 2008. Patients were classified into three groups: age 45 years or younger (group 1), 45-70 years of age (group 2) and 70 years or more (group 3). The variables studied were gender, American Society of Anesthesiologists status, associated comorbidity, type of treatment, length of hospital stay and recurrence of AD.
Group 1 included 99 (14.4%) patients, group 2 339 (49.4%) and group 3 248 (36.2%). Of these, 144 patients needed emergency operation at the first admission, 25 underwent elective surgery after the first episode of AD and 10 died after medical treatment; 507 patients were followed for recurrence. In all, 104 (20.5%) patients had a recurrence of AD that required hospitalization. Fifty (9.9%) presented with one episode of severe recurrence, without any difference between the groups (P = 0.533). There were no differences in the analysis of cumulative recurrence (Kaplan-Maier) between the three groups.
AD does not present a more aggressive clinical course in younger patients and it can be safely managed using the same strategy as in middle aged and older patients.
关于年轻患者急性结肠憩室炎(AD)的表现和治疗存在争议。本观察性研究旨在评估三个不同年龄组患者 AD 的毒力和自然史。
该研究纳入了 1998 年 1 月至 2008 年 12 月期间因首次发作 AD 而入院的 686 例患者。患者被分为三组:45 岁或以下(组 1)、45-70 岁(组 2)和 70 岁或以上(组 3)。研究的变量包括性别、美国麻醉医师协会(ASA)状态、合并症、治疗方式、住院时间和 AD 复发。
组 1 包括 99 例(14.4%)患者,组 2 339 例(49.4%),组 3 248 例(36.2%)。其中,144 例患者在首次就诊时需要紧急手术,25 例在首次 AD 发作后接受择期手术,10 例患者经药物治疗后死亡;507 例患者接受了随访以观察 AD 的复发。共有 104 例(20.5%)患者 AD 复发需要住院治疗。50 例(9.9%)患者出现一次严重复发,但三组之间无差异(P = 0.533)。三组间累积复发(Kaplan-Meier)分析无差异。
AD 在年轻患者中并未表现出更具侵袭性的临床病程,可采用与中老年人相同的策略进行安全管理。