Department of gastroenterology, the Third Affiliated Hospital of Suzhou University, Changzhou, China.
Clin Res Hepatol Gastroenterol. 2012 Apr;36(2):169-77. doi: 10.1016/j.clinre.2011.11.007. Epub 2012 Feb 7.
To detect the association between G870A polymorphism of cyclin D1 (CCND1) gene and colorectal cancer.
We performed a systematic literature and abstract search using PubMed, EMBase digital database. Keywords included CCND1, cyclin D1, polymorphism, SNP, colon cancer, rectal cancer and colorectal cancer. "And", "OR" and "NOT" were used as conjunction to narrow and widen the search. Data were extracted by two investigators independently, and meta-analysis was carried out by using Review Manager 4.2.8. The following pairwised combinations of genotypes for the CCND1 G870A polymorphism were evaluated: AA vs. GG, AG vs. GG, AA+AG vs. GG. Subsequently, sub-group analyses for cancer type, ethnicity, and the family history were performed. Sensitivity analysis was conducted by excluding the articles deviated from Hardy-Weinberg equilibrium.
Using GG genotype as a reference, A carriers were associated with a significantly increased cancer risk (OR=1.15, 95%CI=1.06-1.25, P=0.001, P(heterogeneity)=0.130), especially with rectal cancer (OR=1.24, 95%CI=1.02-1.51, P=0.030, P(heterogeneity)=0.570) and sporadic colorectal cancer (OR=1.26, 95%CI=1.08-1.46, P=0.003, P(heterogeneity)=0.730). The effect of A carriers on cancer also existed in Caucasians (OR=1.19, 95%CI=1.06-1.32, P=0.002, P(heterogeneity)=0.100).
CCND1 G870A polymorphism is associated with the increased risk of colorectal cancer, especially for sporadic colorectal cancer and in Caucasians.
检测细胞周期蛋白 D1（CCND1）基因 G870A 多态性与结直肠癌的关联。
我们使用 PubMed、EMBase 数字数据库进行了系统的文献和摘要搜索。关键词包括 CCND1、细胞周期蛋白 D1、多态性、SNP、结肠癌、直肠癌和结直肠癌。“和”、“或”和“非”被用作连接词来缩小和扩大搜索范围。由两名研究人员独立提取数据，并使用 Review Manager 4.2.8 进行荟萃分析。评估了 CCND1 G870A 多态性的以下两种基因型的配对组合：AA 与 GG、AG 与 GG、AA+AG 与 GG。随后，针对癌症类型、种族和家族史进行了亚组分析。通过排除偏离 Hardy-Weinberg 平衡的文章进行敏感性分析。
以 GG 基因型为参照，A 携带者与癌症风险显著增加相关（OR=1.15，95%CI=1.06-1.25，P=0.001，P（异质性）=0.130），尤其是与直肠癌（OR=1.24，95%CI=1.02-1.51，P=0.030，P（异质性）=0.570）和散发性结直肠癌（OR=1.26，95%CI=1.08-1.46，P=0.003，P（异质性）=0.730）。A 携带者对癌症的影响也存在于白种人（OR=1.19，95%CI=1.06-1.32，P=0.002，P（异质性）=0.100）。
CCND1 G870A 多态性与结直肠癌风险增加相关，尤其是散发性结直肠癌和白种人。
