Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, China.
Cancer Epidemiol. 2012 Apr;36(2):106-15. doi: 10.1016/j.canep.2011.04.007. Epub 2011 May 24.
Published data on the association between Cyclin D1 (CCND1) G870A gene polymorphism and digestive tract cancers (DTC) are inconclusive. We carried out a meta-analysis of published case-control studies to derive a more precise estimation of the association. Relevant studies were identified from PubMed, EMBASE, and China National Knowledge Infrastructure up to February 1st, 2011. Crude odds ratios (OR) and 95% confidence intervals (CI) were used to investigate the strength of the association. Data were available from a total of 33 case-control studies with 8534 cases and 11,737 controls. The combined results based on all studies showed that there was a statistically significant link between CCND1 G870A polymorphism and DTC risk (GG vs. AA: OR=0.83, 95%CI=0.71-0.96). In the analysis of ethnic groups, we found the A allele carriers had a significantly increased DTC susceptibility among Caucasians, but not among Asians. When stratified for tumor location, the results based on all studies only showed the variant allele 870A might have a significantly increased risk of colorectal cancer (CRC), especially of rectal cancer (GG vs. AA: OR=0.71, 95%CI=0.58-0.89). When stratifying by the stage and histological differentiation of CRC, we only observed that patients had a significantly higher frequency of CCND1 870 AA than non-cancer patients among Caucasians. The A allele carriers (hetero- or homozygotes) were significantly more common in cases with a family history of CRC than in controls. There was no evidence of publication bias for CCND1 G870A polymorphism with DTC risk. In summary, this meta-analysis demonstrates that the CCND1 G870A polymorphism may be an ethnicity-dependent risk factor for DTC. And this genetic variant may increase the risk of rectal cancer, but not colon cancer.
关于细胞周期蛋白 D1（CCND1）G870A 基因多态性与消化道癌症（DTC）之间的关联，已发表的数据尚无定论。我们对已发表的病例对照研究进行了荟萃分析，以更精确地评估这种关联。从 PubMed、EMBASE 和中国国家知识基础设施中检索到截止到 2011 年 2 月 1 日的相关研究。使用粗比值比（OR）和 95%置信区间（CI）来研究关联的强度。共有 33 项病例对照研究，总计 8534 例病例和 11737 例对照，提供了可用数据。基于所有研究的综合结果表明，CCND1 G870A 多态性与 DTC 风险之间存在统计学显著关联（GG 与 AA：OR=0.83，95%CI=0.71-0.96）。在对种族群体的分析中，我们发现 A 等位基因携带者患 DTC 的风险显著增加，尤其是在白种人中，但在亚洲人中则不然。按肿瘤位置分层时，基于所有研究的结果仅表明，变异等位基因 870A 可能会显著增加结直肠癌（CRC）的风险，尤其是直肠癌（GG 与 AA：OR=0.71，95%CI=0.58-0.89）。当按 CRC 的分期和组织学分化分层时，我们仅观察到在白种人中，癌症患者的 CCND1 870AA 频率显著高于非癌症患者。有 CRC 家族史的病例中，杂合子或纯合子等位基因携带者的频率明显高于对照组。CCND1 G870A 多态性与 DTC 风险之间没有发表偏倚的证据。综上所述，本荟萃分析表明，CCND1 G870A 多态性可能是 DTC 的一种依赖于种族的危险因素。这种遗传变异可能会增加直肠癌的风险，但不会增加结肠癌的风险。
