Palomba S, Di Cello A, Riccio E, Manguso F, La Sala G B
Academic Department of Obstetrics and Gynecology, University of Modena and Reggio EmiliaS. Maria Nuova Hospital of Reggio Emilia, Italy.
Minerva Endocrinol. 2011 Dec;36(4):295-310.
Gastrointestinal disorders are strictly related to the ovary function. In fact, it is noted that the prevalence of visceral pain disorders such as irritable bowel syndrome, gastroesophageal reflux disease, gallbladder and biliary tract diseases are significantly higher in women. Furthermore, symptom such as nausea, vomiting, abdominal pain, distension, satiety, bloating, diarrhoa or constipation, frequently appears in relation with pregnancy, luteal phase of the menstrual cycle or perimenopausal and menopausal states. Further support for the contribution of ovarian steroids to functional gastrointestinal disorders comes from studies demonstrating that pharmacological ovariectomy reduces abdominal pain symptoms. Therefore, addressing the influence of sex and sex hormones in the modulation of visceral pain appears critical to develop new strategies of diagnosis and therapy sex-directed for gastro-intestinal disorders.
胃肠道疾病与卵巢功能密切相关。事实上，据观察，诸如肠易激综合征、胃食管反流病、胆囊和胆道疾病等内脏疼痛性疾病在女性中的患病率显著更高。此外，恶心、呕吐、腹痛、腹胀、饱腹感、胃胀、腹泻或便秘等症状经常与怀孕、月经周期的黄体期或围绝经期及绝经状态相关。卵巢类固醇对功能性胃肠道疾病有影响这一观点的进一步证据来自于一些研究，这些研究表明药物性卵巢切除可减轻腹痛症状。因此，探讨性别和性激素在内脏疼痛调节中的作用，对于制定针对胃肠道疾病的性别导向性诊断和治疗新策略似乎至关重要。
