Jung Ui-Won, Lee Jung-Seok, Park Weon-Yeong, Cha Jae-Kook, Hwang Ji-Wan, Park Jung-Chul, Kim Chang-Sung, Cho Kyoo-Sung, Chai Jung-Kiu, Choi Seong-Ho
Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.
J Periodontal Implant Sci. 2011 Dec;41(6):285-92. doi: 10.5051/jpis.2011.41.6.285. Epub 2011 Dec 31.
The aim of this study was to elucidate the effect of a bovine hydroxyapatite/collagen (BHC) block in one-wall intrabony periodontal defects in dogs.
A one-wall intrabony periodontal defect (4 mm wide and 5 mm deep) was prepared bilaterally at the mesial side of the mandibular fourth premolar in five beagle dogs. After thorough root planing, block-type BHC (4×5×5 mm) was placed on one side. The contralateral defect area did not receive any material as a sham-surgery control. Histological analysis of the sites was performed after an 8-week healing period.
Two of five samples in the experimental group healed well without dissipation of the graft materials, and histological analysis revealed excellent regeneration of the periodontal tissues. However, most of the grafted materials had been displaced in the other three samples, leaving only a small portion of the graft. The measured parameters exhibited large standard deviations, and the mean values did not differ significantly between the experimental and sham-surgery control sides.
The application of BHC alone-without a barrier membrane-to wide, one-wall intrabony periodontal defects yielded inconsistent results regarding both periodontal regeneration and substantivity of the graft materials. Thus, the use of a barrier membrane for noncontained-type defects is recommended to improve the stability of the grafted material, and to condense it.
本研究旨在阐明牛羟基磷灰石/胶原蛋白（BHC）块对犬单壁骨内牙周缺损的影响。
在5只比格犬下颌第四前磨牙近中侧双侧制备单壁骨内牙周缺损（宽4mm，深5mm）。彻底根面平整后，在一侧放置块状BHC（4×5×5mm）。对侧缺损区不植入任何材料作为假手术对照。8周愈合期后对这些部位进行组织学分析。
实验组5个样本中有2个愈合良好，移植材料未消散，组织学分析显示牙周组织再生良好。然而，其他3个样本中的大多数移植材料已移位，仅留下一小部分移植材料。测量参数的标准差较大，实验组和假手术对照侧的平均值无显著差异。
在无屏障膜的情况下，单独应用BHC治疗宽的单壁骨内牙周缺损，在牙周再生和移植材料的存留方面均产生了不一致的结果。因此，对于非封闭型缺损，建议使用屏障膜以提高移植材料的稳定性并使其浓缩。
